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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987-04-27 to 1987-06-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study (OECD), non-GLP but internally audited.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Principles of method if other than guideline:
Test item application: soaked test patch instead of exactly 0.5 mL
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyruvaldehyde
EC Number:
201-164-8
EC Name:
Pyruvaldehyde
Cas Number:
78-98-8
Molecular formula:
C3H4O2
IUPAC Name:
2-oxopropanal

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler, Offenbach/Main, Germany
- Age at study initiation: not specified
- Weight at study initiation: 221 and 2.53 (two males); 2.21 (one female)
- Housing: Stainless steel cage with wire mesh walk floor (floor area: 40 x 51 cm)
- Diet: about 130 g /animal / day
- Water: about 250 mL tap water / animal / day
- Acclimation period: at least 8 days

ENVIRONMENTAL CONDITIONS
- Temperature: 20 - 24°C
- Humidity: 30 - 70 %
- Air changes: not specified ("fully air conditioned")
- Photoperiod: 12 hrs dark / 12 hrs light

IN-LIFE DATES: From 1987-04-27 up to 1987-06-07

Test system

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount applied: wetted test patch (estimation in report: "0.5 mL of liquid was absorbed")
- Concentration: 30% ("ber. 100%")
Duration of treatment / exposure:
4h
Observation period:
72h (and subsequently from 17 to 40 days, depending on animal)
Animal #1 (female, 0769): 25 days
Animal #2 (male, 0762): approximately 40 days. Found dead, cause of death: accidental ( 360° torsion of hepatic lobe)
Animal #3 (male, 0745): 17 days
Number of animals:
2 males, 1 female
Details on study design:
TEST SITE
- Area of exposure: one site per rabbit on the upper third of the back or flanks
- % coverage: approximately 2.5 x 2.5 each


REMOVAL OF TEST SUBSTANCE
- Washing: yes, at the end of exposure with Lutrol and Lutrol / water (1:1)


SCORING SYSTEM: Draize score

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24, 48 and 72h (mean)
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24, 48 and 72h (mean)
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24, 48 and 72h (mean)
Score:
0.66
Max. score:
4
Reversibility:
fully reversible within: 72h
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24, 48 and 72h (mean)
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24, 48 and 72h (mean)
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24, 48 and 72h (mean)
Score:
0
Max. score:
4

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
Classification: not irritating