Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-164-8 | CAS number: 78-98-8
Endpoint summary
Administrative data
Description of key information
The test item was tested for skin irritation/corrosion properties in a non-GLP study according to OECD 404 with rabbits. The test item was classified as not irritating to the skin.
The test item was tested for eye irritation properties in a GLP study according to OECD 405 with rabbits and was found to cause serious damage to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin:
Pyruvaldehyde was tested for skin irritation/corrosion properties in a non-GLP study with rabbits according OECD 404. A test patch was soaked with the undiluted test item. It was estimated in the study report that 0.5 mL of liquid was absorbed. The patch was applied to the dorsal skin and ear of three Vienna white rabbits. Exposure duration was 4 hours. The test substance caused slight (one animal, reversible) or no (two animals) erythema and no edema in all animals. After the 8 days observation, no effects were visible on the dorsal exposure sites. The test item was classified non irritating to the skin (BASF AG, 1987).
Eye:
Pyruvaldehyde was tested for eye irritation properties in a GLP study according to OECD 405 using rabbits. The test item was applied unchanged (30%) at a dose of 0.1 mL to the right eye of three Vienna white rabbits. Necropsy of one animal found dead on day 3 diagnosed a coccidia infection, and in consequence only data from 24 and 48 h were available from this animal. Both remaining rabbits were euthanased on day 15 due to severe irritation at the cornea (Draize score cornea: 3 or 4) and the conjunctiva (redness score: both 2; chemosis score: both 1). The test item was therefore classified as an eye irritant (BASF, 1987).
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Based on the results, classification for skin irritation is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
Based on the results of the in vivo eye irritation study, the test substance is classified as Xi, R41 (risk of serious damage to eyes) according to the criteria of EU Directive 67/548/EEC and as eye damage cat. 1, H318 (Causes serious eye damage) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
