Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

4-(vinyloxy)butan-1-ol is acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Additional information

Assessment of the toxicity of 4 -(vinyloxy)butan-1 -ol towards aquatic invertebrates is based on data available for two close structural analogous substances: 2-methyl-1-(vinyloxy)propane and 2 -(vinyloxy)ethanol.

The toxicity of 2-methyl-1-(vinyloxy)propane (CAS 109 -53 -5) to aquatic invertebrates was examined in a study according to OECD TG 202 and in compliance with GLP criteria (BASF, 2004). In this study, groups of daphnids (4 replicates of 5 animals) were exposed to the substance at nominal concentrations of 0 (control), 4.8, 9.5, 19, 38, 75, 150 and 300 mg/L in sealed vessels for 48 hours under static conditions. Nominal concentrations were analytically verified and recoveries ranged from ca. 98 to 177% at the start of the test and from ca. 88 to 150% after the 48 -hour exposure period. Mobility of exposed daphnids was recorded after 24 and 48 exposure. A 5% reduction of mobility was first seen at a nominal test concentration of 19 mg/L. At 38 mg/L immobility had increased to 10% and at higher tested concentrations immobility was 100%. Based on these findings, an 48 -h EC50 of 52.0 mg/L was determined (based on measured concentrations). After correction for difference in molecular weight between the read-across source and target substances, the 48 -h LC50 for 4-(vinyloxy)butan-1-ol is 60 mg/L.

A second test with daphnids was performed with 2 -(vinyloxy)ethanol (CAS 764 -48 -7) (BASF, 1999). In this study, which was performed according to OECD TG 202 and in compliance with GLP criteria, groups of daphnids (4 replicates of 5 animlas) were exposed to the substance at nominal concentrations of 0 (control), 12.5, 25, 50 and 100 mg/L for 48 hours under static conditions. Mobility of daphnids was recorded after 24 and 48 hour exposure. No significant immobility was seen in the test. The 48 -h EC50 was determined at >100 mg/L. Based on the log Kow of this substance, it is considered to have less potential for aquatic toxicity than 4 -(vinyloxy)butan-1 -ol and therefore this data is considered as supporting information only.

The 48 -h EC50 value of 60 mg/L from the study with 2-methyl-1-(vinyloxy)propane (CAS 109 -53 -5) is used for assessment.