Registration Dossier
Registration Dossier
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EC number: 237-875-5 | CAS number: 14038-43-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Toxicity to reproduction
The Prussian blue has very low order of toxicity.It is likely to given by oral route .It has high molecular weight i.e 877.381g/mole and limited absorption from gut,99% of the administered Prussian blue dose was excreted unchanged in faeces,(HSDB) andhence this end point is considered for waiver.
Link to relevant study records
- Endpoint:
- reproductive toxicity, other
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because (i) the substance is of low toxicological activity (no evidence of toxicity seen in any of the tests available), (ii) it can be proven from toxicokinetic data that no systemic absorption occurs via relevant routes of exposure (e.g. plasma/blood concentrations below detection limit using a sensitive method and absence of the substance and of metabolites of the substance in urine, bile or exhaled air) and (iii) there is no or no significant human exposure
- other:
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Waiver
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Toxicity to reproduction
The Prussian blue has very low order of toxicity.It is likely to given by oral route .It has high molecular weight i.e 877.381g/mole andlimited absorption from gut,99% of the administered Prussian blue dose was excreted unchanged in faeces,(HSDB) andhence this end point is considered for waiver.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Toxicity to reproduction
The Prussian blue has very low order of toxicity.It is likely to given by oral route .It has high molecular weight i.e 877.381g/mole andlimited absorption from gut,99% of the administered Prussian blue dose was excreted unchanged in faeces,(HSDB) andhence this end point is considered for waiver.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
