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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from authoritative database
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The toxicokinitic study of Prussian blue insoluble was performed on pig
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: Prussian blue
- IUPAC name: C.I.Pigment Blue 27
- Molecular formula: C6FeN6.4/3Fe
- Molecular weight (if other than submission substance): 859.23 g/mol
- Smiles : [CH-](#N)[Fe+2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)[CH-]#N.[CH-](#N)[Fe+2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)[CH-]#N.[CH-]
(#N)[Fe+2]([CH-]#N)([CH-]#N)([CH-]#N)([CH-]#N)[CH-]#N.[Fe+3].[Fe+3].[Fe+3].[Fe+3]
- Inchi : 1S/18CN.7Fe/c18*1-2;;;;;;;/q18*-1;3*+2;4*+3
- Substance type: Inorganic
- Physical state: Solid powder (dark blue)
Radiolabelling:
yes
Species:
pig
Strain:
not specified
Details on species / strain selection:
No data available
Sex:
not specified
Details on test animals and environmental conditions:
No data available
Route of administration:
oral: capsule
Vehicle:
not specified
Details on exposure:
No data available
Duration and frequency of treatment / exposure:
No data available
Dose / conc.:
40 mg/kg bw/day (nominal)
No. of animals per sex per dose:
38
Control animals:
not specified
Positive control:
No data available
Details on study design:
No data available
Details on dosing and sampling:
No data available
Statistics:
No data available
Preliminary studies:
No data available
Type:
excretion
Results:
99% of the administered Prussian blue dose was excreted unchanged in feces
Details on absorption:
Test material poorly absorb
Details on distribution in tissues:
No data available
Transfer type:
other: No data available
Observation:
not determined
Details on excretion:
99% of the administered Prussian blue dose was excreted unchanged in feces
Test no.:
#1
Toxicokinetic parameters:
other: 99% excreted unchanged in feces
Metabolites identified:
not specified
Details on metabolites:
No data available
Bioaccessibility testing results:
No data available
Conclusions:
The toxicokinitic study of Prussian blue insoluble was performed on pig. 38 animals were used. A single dose of 40 mg labelled Prussian blue insoluble were adminstered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces, therefore is likely to have low bio-accumulation potential
Executive summary:

The toxicokinitic study of Prussian blue insoluble was performed on pig. 38 animals were used. A single dose of 40 mg labelled Prussian blue insoluble were administered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces,therefore is likely to have low bio-accumulation potential

Description of key information

The bio-accumulation potential of the target chemical Prussian blue insoluble (14038-43-8).In-vivo studies in pig .A single dose of 40 mg labelled Prussian blue insoluble were administered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces, Therefore, it has been concluded that the target chemical is also unlikely to bio-accumulate in-vivo.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
1

Additional information

The bio-accumulation potential of the target chemical Prussian blue insoluble (14038-43-8).In-vivo studies in pig .A single dose of 40 mg labelled Prussian blue insoluble were administered orally. 99% of the administered Prussian blue dose was excreted unchanged in feces, Therefore, it has been concluded that the target chemical is also unlikely to bio-accumulate in-vivo.