Registration Dossier
Registration Dossier
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EC number: 245-854-7 | CAS number: 23735-96-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPISKIN-SM reconstituted human epidermis
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N6-(1-oxooctyl)-L-lysine
- EC Number:
- 245-854-7
- EC Name:
- N6-(1-oxooctyl)-L-lysine
- Cas Number:
- 23735-96-8
- Molecular formula:
- CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
- IUPAC Name:
- (2S)-2-amino-6-octanamidohexanoic acid
Constituent 1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: in vitro assay; cell viability (MTT assay)
- Value:
- 0.508
- Remarks on result:
- other:
- Remarks:
- Time point: 4 hrs. Remarks: Viability: 79% - Neg. control: 0.641 or 100%; Pos. control: 0.015 or 2.4%. (migrated information)
In vivo
- Irritant / corrosive response data:
- The test item is not corrosive.
Applicant's summary and conclusion
- Conclusions:
- Amihope OL was not a skin corrosive in the EPISKIN model test.
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