Registration Dossier
Registration Dossier
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EC number: 245-854-7 | CAS number: 23735-96-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- N6-(1-oxooctyl)-L-lysine
- EC Number:
- 245-854-7
- EC Name:
- N6-(1-oxooctyl)-L-lysine
- Cas Number:
- 23735-96-8
- Molecular formula:
- CH3-(CH2)6-CO-NH-(CH2)4-CH(-NH2; -COOH)
- IUPAC Name:
- (2S)-2-amino-6-octanamidohexanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Test animals: Crl:WI (Charles River Deutschland)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2 x 3 rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: On the day of application, after 0.5, 2 and 4 hrs piloerection was observed in all 6 rats. Additionally, all 6 rats showed a hunched posture after 2 hrs. After 6 hrs and from day 1 to day 14, all rats were free of any abnormalities.
- Gross pathology:
- No pathological signs observed
Applicant's summary and conclusion
- Conclusions:
- The oral LD50 is >2000 mg/kg b.w. Not classified
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