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EC number: 278-636-5 | CAS number: 77182-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are several case reports available in literature. However, these reported cases mainly refer to acute poisoning with the formulated products, not with the active ingredient (GA) itself. In poisonings with products containing Glufosinate ammonium the surfactants in the formulation, as well as the other ingredients, may play an important role for some of the symptoms observed.
The main findings of these reports are summarized as follows:
Human poisoning cases resulted in nausea, vomiting, diarrhea, abdominal pain, tremor, hypotension, bradycardia or tachycardia, muscle weakness, drowsiness, loss of consciousness and coma, convulsions, and respiratory arrest. Rarely hyperthermia has been described, as has in one case of ingestion of a very high dose diabetes insipidus, and in one case double vision and nystagmus due to palsy of the 6th cranial nerve. Retro- and anterograde amnesia and memory deficits can occur. The fatality rate in reported poisonings is about 18%. The neurological symptoms may suddenly appear with a delay (latency period) of 8 to 48 hours
without warning. Both cytotoxic and vasogenic edema have been reported in brain regions.
Additional information
Based on the effects on the human central nervous system reported after single exposures to GA formulations and based on the fact that these effects have also been reported in animals exposed to the pure substance, glufosinate ammonium is classified for target organ toxicity (central nervous system) in accordance with Regulation (EC) 1272/2008 (STOT SE Cat.1; H370).
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