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EC number: 203-402-6 | CAS number: 106-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April to June 1980
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail, test method comparable to guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-chlorophenol
- EC Number:
- 203-402-6
- EC Name:
- 4-chlorophenol
- Cas Number:
- 106-48-9
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 4-chlorophenol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- TNO/W 74
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Recognised animal supplier.
- Age at study initiation: Not reported.
- Weight at study initiation: 150 - 200 g
- Fasting period before study: Not reported
- Housing: Makrolon type III or II cages.
- Diet: Altromin-R maintenance diet for rats and mice, ad libitum.
- Water: ad libitum
- Acclimation period: Not reported.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported.
- Humidity (%): Not reported.
- Air changes (per hr): Not reported.
- Photoperiod (hrs dark / hrs light): Not reported.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- poloxamer
- Remarks:
- given by its alternative trade name "Lutrol" in study report.
- Details on oral exposure:
- Administered once via ,,Schlundsonde'' ("Gullet-tube"), i.e. oral gavage.
- Doses:
- 100, 500, 750, 1000, 1500, 2000 and 2500 mg/kg bw (M); 100, 250, 500, 600, 750, 1000, 1250, 1750 and 2000 mg/kg bw (F).
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: At least once daily for 14 days.
- Necropsy of survivors performed: Yes.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 258 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 988 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortalities occurred.
- Clinical signs:
- other: Poisoning symptoms occured about 5 minutes after treatment, including disturbances of general behaviour (apathy), laboured breathing, convulsions, tremors, and lying in prone/lateral positions. The symptoms persisted in surviving animals for up to 24 hour
- Gross pathology:
- Post-mortem examinations of mortalities indicated pale, spotted livers, spleen and kidneys. Empysematous lung-changes were also noticeable. No pathalogical features were found in surviving animals upon euthanisation at the end of the study period. (Translated from German).
Any other information on results incl. tables
Table 1: Acute oral toxicity in "soberly-handled" rats (translated from German)
Dose [mg/kg bw] | Toxicology Result [Dead / With Symptoms / Total Used] | Time of Death following Treatment | LD50 (14 -days) [mg/kg bw] |
Male Rats | |||
100 | 0/0/10* | - | 1258 (1044 - 1502) b = 5.92** |
500 | 0/10/10 | - | |
750 | 1/10/10 | 1h 13' | |
1000 | 3/10/10 | 2h 32' | |
1500 | 7/10/10 | 1h 30' - 4h 20' | |
2000 | 8/10/10 | 0h 15' - 24h 0' | |
2500 | 10/10/10 | 0h 50' - 4h 20' | |
Female Rats | |||
100 | 0/10/10* | - | 988 (841 - 1164) b = 5.63** |
250 | 0/10/10 | - | |
500 | 0/10/10 | - | |
600 | 2/10/10 | 1h 40' | |
750 | 3/10/10 | 2h 15' - 24h 0' | |
1000 | 4/10/10 | 1h 5' - 2h 10' | |
1250 | 7/10/10 | 0h 32' - 2h 47' | |
1750 | 9/10/10 | 0h 20' - 4h 20' | |
2000 | 10/10/10 | 0h 30' - 24h 0' |
* Maximum dose without negative effects
** Regression coefficient
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- EU criteria met
- Conclusions:
- Under the conditions of this study the LD50 was determined to be 1258 mg/kg bw in the male Wistar rat and 988 mg/kg bw in the female Wistar rat.
- Executive summary:
The study was performed following a method equivalent or similar to OECD TG 401 to assess the acute oral toxicity potential of the test substance to male and female Wistar rats. The test item was administered as a single dose via oral gavage to groups of 10 male and 10 female rats per dose-level orally. Under the conditions of this study the LD50 was determined to be 1258 mg/kg bw for male Wistar rats and 988 mg/kg bw for female Wistar rats.
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