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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-09-16 to 2013-11-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- 9.46 mg of the internal standard methyl tetracosanoate are dissolved in 100 ml of t-butyl methyl ether (TBME) = internal standard stock solution. Of this stock solution 1 ml is transferred into a 10 ml volumetric flask and topped up to the mark with TBME = internal standard solution.
After defined incubation times, 20 ml of the test solutions are transferred into 50 ml volumetric flasks. 10 µI of the internal standard solution are added, and the analyte as well as any possible degradation products and the internal standard substance are extracted with 10 ml of t-butyl methyl ether (TBME) by stirring for 1 hour.
After stirring of the 20 ml test solution· aliquots in TBME for extraction the ether phase is dried using sodium sulfate, evaporated to an end volume of 2 ml and analysed by gas chromatography/mass spectrometry coupling. - Buffers:
- Buffer solution pH 4, AVS Titrinorm, Batch 13G010501
Buffer solution pH 7, AVS Titrinorm, Batch 13F120512
Buffer solution pH 9, Bernd Kraft, Batch 1473336 - Details on test conditions:
- The stability of the test item in aqueous systems is investigated at pH 4, pH 7, and pH 9 at 20 °C, 50 °C and 70 °C.
A stock solution of the test item of 55.24 mg/50 ml in ethanol is prepared. 500 µI of this solution is transferred into a 500 ml volumetric flask and topped up to the mark with the respective buffer solutions.
For each pH and each temperature duplicate test solutions were prepared.
Duration of testopen allclose all
- Duration:
- 4 h
- pH:
- 9
- Temp.:
- 70 °C
- Duration:
- 24 h
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 72 h
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 2 h
- pH:
- 7
- Temp.:
- 70 °C
- Duration:
- 2 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 24 h
- pH:
- 7
- Temp.:
- 20 °C
- Number of replicates:
- 2
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- Details on hydrolysis and appearance of transformation product(s):
- After hydrolysis of the test item, the test solutions were investigated by GC-M to identify the hydrolysis products. The obtained data was compared with reference spectra collected in non-GLP preliminary study. The observed product is one of the starting materials used in the synthesis of Sa 57. Due to the same molecular mass, the two isomers of the aldehyde cannot be distinguished by the test method used for their identification (GC-MS), but both are expected to be present.
The other reaction product was not identified in the course of the study. Due to the high polarity of this component, it was not possible to extract it from the aqueous phase in significant enough amounts to identify it by subsequent GC-MS analysis.
It is our opinion, that despite not being identified by the analytical techniques used in this study, its presence as hydrolysis product is clearly established by the detection of the aldehyde. The hydrolysis represents the reverse reaction of the synthesis of the test item and leaves no other plausible options for other hydrolysis products.
Dissipation DT50 of parent compoundopen allclose all
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- Remarks on result:
- not determinable
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- not determinable
- Key result
- pH:
- 4
- Temp.:
- 70 °C
- Remarks on result:
- not determinable
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0.805 h-1
- DT50:
- 0.9 h
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 2.574 h-1
- DT50:
- 0.3 h
- Key result
- pH:
- 7
- Temp.:
- 70 °C
- Hydrolysis rate constant:
- 2.574 h-1
- DT50:
- 0.3 h
- Key result
- pH:
- 9
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0.006 h-1
- DT50:
- 11.9 h
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0.177 h-1
- DT50:
- 3.9 h
- Key result
- pH:
- 9
- Temp.:
- 70 °C
- Hydrolysis rate constant:
- 1.248 h-1
- DT50:
- 0.6 h
- Details on results:
- At pH 7, the rate constants for 50 °C and 70 °C were determined to be equal. This is caused by the fast hydrolysis and experimental restrictions regarding the sampling rate and is not in contradiction to the expectation that the hydrolysis should be faster at higher temperatures.
The temperature dependence of the rate constant at pH 4 could not be determined. At pH 4 an immediate hydrolysis takes place; the test item cannot be detected.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Sa 57 is hydrolytically unstable at ph4, ph7 and ph9.
- Executive summary:
The hydrolysis as a function of pH of Sa 57 is determined according to OECD Guideline for the Testing of Chemicals No. 111.
Sa 57 is hydrolytically unstable at ph4, ph7 and ph9.
The temperature dependence of the rate constant at pH 4 could not be
determined. At pH 4 an immediate hydrolysis takes place; the test item cannot be
detected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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