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EC number: 403-140-4 | CAS number: 103694-68-4 MAJANTOL; MAJANTOL R
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-07-19 to 2000-09-12
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no adsorption control
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Version / remarks:
- 1992
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Municipal sewage treatment plant, Hildesheim; Germany
- Pretreatment: The activated sludge was filtered.The filtrate was maintained in aerobic condition by aeration until test begin.
- Colony forming units of the inoculum: 3.7 x 10^5 CFU/mL - Duration of test (contact time):
- 56 d
- Initial conc.:
- 19.9 mg/L
- Based on:
- other: ThTOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral nutrient solution acc. to OECD 301 E
- Test temperature: 22 +/- 2°C
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 2L Erlenmeyer flasks
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: The vessels were stirred continuously with magnetic bars.
SAMPLING
- Sampling frequency: samples were taken at regular time intervals (0, 1, 5, 7, 14, 21, 28, 35, 49 and 56 days).
CONTROL AND BLANK SYSTEM
- Inoculum blank: Duplicates
- Reference compound: single replicate
- Control: Nutrient solution and inoculum, duplicates
- Toxicity control: yes, single replicate - Reference substance:
- other: Sodium acetate
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 16
- Sampling time:
- 56 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 7
- Sampling time:
- 28 d
- Details on results:
- 7% degradation after 28 d, 16% degradation after 56 days,70% pass level and 10-day window were not met.
In the toxicity control containing both test (19.9 mgC/L) and reference item (130 mg/L), the biodegradation came to 64 % after 14 days. The test item can be assumed to be not inhibitory in the test. - Results with reference substance:
- 97% after 14 d, >= 70% pass level was reached.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- This study indicates that the substance is not readily biodegradable (16% after 56 d (TOC consumption, OECD 301E)).
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987-10-06 til 1987-11-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): From a well-operated municipal sewage treatment plant (Hamburg-Neuenfelde). This sewage treatment receives no or minimal effluents from industry.
- Preparation of inoculum for exposure: Upon arrival at the laboratory, the activated sludge was aerated for 4 hours. 500 ml of the mixed liquor was sampled and homogenised for 2 minutes at medium speed in a waring blender. lt was then settled for ca. 30 min. The supernatant was decanted to provide sufficient volume for a 1 per cent inoculum for each CO2 test flask. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: According to guideline
- Test temperature: 20-21°C
- pH: 7.6
TEST SYSTEM
- Culturing apparatus: 5 Litre disposable amber carboys
- Number of culture flasks/concentration: 1 per concentration (10 and 20 mg/L)
SAMPLING
- Sampling frequency: Day 1, 2, 3, 6, 9, 13, 17, 21, 27, 28
- Sampling method: For sampling the CO2 adsorber nearest the carboy was removed for titration. The remaining two adsorbers were each moved one place closer to the carbox, and a new adsorber filled with 100 ml of fresh 0.025 N Ba(OH)2 was made as needed (before any BaCO3 precipitate was evident in the second trap).
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 1 replicate
- Toxicity control: No - Reference substance:
- other: sodium-n-dodecylsulfate
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 4
- Sampling time:
- 28 d
- Details on results:
- The amount of CO2 produced by the test sample was found to 3 - 4 % after 10 days and did not increase by the end of the test.
- Results with reference substance:
- > 60% after 10 days and 86% after 28 days (tested concentration: 20 mg/L)
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- This study indicates that the substance is not readily biodegradable (4% after 28 d (CO2 evolution, OECD 301B)).
Referenceopen allclose all
Biodegradation of the test item in comparison to the functional control and the toxicity control
|
Biodegradation [%] |
||||||
Study day [d] |
|||||||
7 |
14 |
21 |
28 |
35 |
49 |
56 |
|
Test item (19.9 mgC/L) |
0 |
0 |
8 |
7 |
10 |
18 |
16 |
Funcional control (130 mg/L) |
95 |
97 |
88 |
88 |
- |
89 |
100 |
Toxicity control (19.9 mgC/L (test item) + 130 mg/L reference item) |
64 |
64 |
64 |
64 |
67 |
69 |
69 |
Description of key information
Not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
All available experimental studies indicate that the substance is not readily biodegradable.
In an OECD 301E (TOC consumption) test 16% biodegradation was observed after 56 days. In an OECD 301B (CO2 evolution) test 4% biodegradation was observed after 28 days.
In the toxicity control of the OECD 301E test containing both test (19.9 mgC/L) and reference item (130 mg/L), the biodegradation came to 64 % after 14 days. Thus, it can be assumed that the test item was not inhibitory in the test.
Therefore the test substance should be regarded as not readily biodegradable.
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