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EC number: 602-927-1 | CAS number: 123312-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Nov 1992 to 22 Mar 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Register 40 CFR part 796.1840
- Version / remarks:
- 1985
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Treatment of test material prior to testing:
Since test substance is known to hydrolyse at pH values below 7, solutions for the experiment were prepared containing around ten times the amount of the substance necessary for saturation to ensure that the solutions remained saturated during the experiment.
On each of the first three days of the experiment, 3 such samples were prepared in centrifuge tubes and equilibrated by continuous shaking at 30.0 °C (± 0.1 °C) in a thermostatically controlled water bath. On the fourth day the temperature was reduced to 25.0 °C (± 0.1 °C), at which temperature each sample was shaken further for at least 24 hours. The dispersions were then centrifuged for 40 minutes at 30000, 40000 or 50000 G in a thermostated (25.0 °C) centrifuge. After centrifugation it was noted that all the test solutions were still cloudy with residual test substance at the bottom of the centrifuge tube. The test solutions were therefore decanted into similar centrifuge tubes, taking care to remove much but not all of the excess test substance. The centrifuge tubes were then re-equilibrated by continuous shaking at 25.0 °C (± 0.1 °C) for a further 3 days. Thereafter the majority of the excess test substance was removed by pipette and the tubes then centrifuged for 80 minutes at 50000 G in the thermostated (25 °C) centrifuge. After centrifugation clear solutions were obtained. Each test solution, however, still contained excess test substance. Subsequently, an aliquot from each of the clear, saturated solutions was analysed by high performance liquid chromatography, HPLC. Equilibration at 30.0 °C for different lengths of time gave the same results indicating that true saturation had been reached and maintained. - Key result
- Water solubility:
- 290 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 5 - <= 7 d
- Temp.:
- 25 °C
- pH:
- 6.4
- Remarks on result:
- other: RSD: 0.91% (average of 9 samples)
- Details on results:
- An overview of the results is presented in ‘Any other information on results incl. tables’.
- Conclusions:
- The water solubility of the test item was determined to be 290 mg/L in water at 25 °C and pH 6.4.
- Executive summary:
The water solubility of the test item has been determined using the flask method in accordance with OECD TG 105 and in compliance with GLP. The solubility (average of 9 samples), of the pure test substance in water was determined to be 290 mg/L at 25 °C and pH 6.4.
Reference
Table: Equilibration at 30.0 °C for 3, 2 and 1 days
sample number |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
Weight of test substance in 40.0 mL of water [mg] |
80.3 |
80.1 |
80.2 |
79.7 |
78.6 |
82.0 |
84.3 |
82.0 |
82.3 |
number of days at 30.0 °C |
3 |
3 |
3 |
2 |
2 |
2 |
1 |
1 |
1 |
number of days at 25.0 °C |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
4 |
Centrifugation [G] |
50000 |
50000 |
50000 |
50000 |
50000 |
50000 |
50000 |
50000 |
50000 |
pH of clear solution |
6.52 |
6.60 |
6.35 |
6.55 |
6.49 |
6.34 |
6.36 |
6.45 |
6.37 |
average pH value |
6.5 |
6.5 |
6.4 |
||||||
water solubility in mg/L 1 determination 2 determination 3 determination average |
287.210 292.564 291.560 290.445 |
285.942 285.751 286.733 286.142 |
286.502 287.719 282.898 285.142 |
290.344 287.923 288.638 288.968 |
289.784 290.583 291.534 290.634 |
287.190 286.787 286.411 286.796 |
292.335 292.448 286.286 290.356 |
290.590 290.394 292.585 291.190 |
291.015 291.568 290.501 291.028 |
total average |
287.431 mg/L |
288.799 mg/L |
290.858 mg/L |
||||||
rel. standard deviation |
1.0 % |
0.64 % |
0.66 % |
Description of key information
290 mg/L in water at 25 °C, OECD 105, flask method, Rodler 1993
Key value for chemical safety assessment
- Water solubility:
- 290 mg/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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