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EC number: 813-358-5 | CAS number: 4886-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1-phenyl-3-(phenylsulfamoyl)urea
- EC Number:
- 813-358-5
- Cas Number:
- 4886-26-4
- Molecular formula:
- C13H13N3O3S
- IUPAC Name:
- 1-phenyl-3-(phenylsulfamoyl)urea
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 51.85 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 3.46 - <= 3.58
Applicant's summary and conclusion
- Conclusions:
- At the plateau, the concentration of N-Phenyl-N'-[phenylamino)sulfonyl]urea in water had reached 51.85 ± 0.37 mg/L at 20.0 ± 0.5 °C
- Executive summary:
The solubility of the test itemN-Phenyl-N'-[phenylamino)sulfonyl]urea in water was determined by measurement of the test item concentration in the filtrated test solutions using HPLC.
The preliminary test which is described in the guideline was not performed as the solubility of the test item was estimated during validation of the analytical method as 64.46 ± 0.35 mg/L (measured in a solution with a nominal concentration of 15 g test item/L).
According to the guideline, the flask method was used for the determination of the solubility of the test item in water.
In the main test,one loading rate of the test item was chosen: 1000 mg/L (nominal). Three flasks 1A - C were used during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h) and 2 – 6) were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature (20.0 ± 0.5 °C). Then, flasks 1A - 1C were taken from the shaker, samples were taken, membrane filtered and analysed via HPLC. No rising tendency in the test item concentration of the solutions was found on day 3. Therefore, the plateau of the test item solubility had been reached.
No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles were present.
At the plateau, the concentration ofN-Phenyl-N'-[phenylamino)sulfonyl]ureain water had reached
51.85 ± 0.37 mg/L at 20.0 ± 0.5 °C
= 5.185 ± 0.037 * 10-5kg/m3(SI units)
(mean value ± standard deviation of five individual vessels)
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