Registration Dossier
Registration Dossier
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EC number: 232-189-2 | CAS number: 7789-78-8
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of calcium hydride has been waived. CaH2 reacts violently or is ignited by air; reacts exothermically with water or moisture producing hydrogen and calcium hydroxide, releases flammable gases on contact with water. Due to these physico-chemical properties, CaH2 was not tested for the oral acute toxicity.
Nevertheless, CaH2 once reacted with either moisture or water, the substance produces gas (hydrogen) and calcium hydroxide. Therefore, a read-across with calcium hydroxide was also reported for this endpoint. According the existing study for oral acute toxicity made with OECD guideline N°425 on female rats with calcium dihydroxide, the LD50 is >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity test following OECD guideline N°425 ran with female rats with calcium dihydroxide, no deaths occurred at the limit dose of 2000 mg/kg bw. Therefore, the LD50 is >2000 mg/kg bw.
Referenceopen allclose all
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
