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EC number: 204-854-7 | CAS number: 127-65-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 October 1978 - 14 November 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study is performed pre-GLP and method is comparable to OECD 403. Method is well described but reporting of results is done with little detail. No necropsy was performed. Bodyweight of the animals are not recorded. Responses of individual animals are not shown. Since test substance preparation and animal exposure are described in detail the study is considered valid with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- The study was performed according to an in-house method from TNO (Zeist, The Netherlands) this method was comparable to OECD403.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tosylchloramide sodium
- EC Number:
- 204-854-7
- EC Name:
- Tosylchloramide sodium
- Cas Number:
- 127-65-1
- Molecular formula:
- (C7H4SO2NCl)Na
- IUPAC Name:
- sodium chloro(4-methylbenzenesulfonyl)azanide
- Details on test material:
- Test substance: Chloramine-T
Appearnce: white powder.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Central Institute for the Breeding of Laboratory Animals TNO, Zeist , The Netherlands.
- Age at study initiation: no data
- Weight at study initiation: males 182g and females 140g
- Fasting period before study: none, during the study period the animals did not have access to food.
- Housing: The animals were exposed in a stainless steel exposure chamber with a capacity of 1.5 m3. In the exposure chamber the animals were individually housed in wire-screen cages. They could continuously be observed through the hard glass entrance door of the chamber. During the 14-day observation period the animals were housed in stainless steel cages which were suspended in an open rack.
- Diet (e.g. ad libitum): ad libitum, institute's stock diet for rats.
- Water (e.g. ad libitum): ad libitum, bottled unfluorinated water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 1
- Humidity (%): 40-50
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: 31 October 1978 To: 14 November 1978
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel exposure chamber
- Exposure chamber volume: 1.5 m3
- Method of holding animals in test chamber: wire-screen cages.
- Source and rate of air: air flow rate of 0.84 m3/h.
- Method of conditioning air: no data
- System of generating particulates/aerosols: "Wright" Dust Feed Mechanism
- Method of particle size determination: Particle size determinations and counts were carried out in samples taken from the atmosphere in the chamber with a Cascade impactor.
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
- Brief description of analytical method used: The concentration of the dispersed Chloramine T was determined gravimetrically by passing a measured amount of the test atmosphere through a glassfibre filter.
- Samples taken from breathing zone: no
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Particle size determinations in impaction samples revealed a maximum particle diameter of 6.7 µm. Eighty percent of the dispersion consisted of particles with a diameter of 0.8-4.7 µm.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): no data - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- continuously at a max. conc. of 275 mg/m3 air
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data - Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 275 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- no mortality
- Clinical signs:
- other: During the first 30 minutes of the exposure period the rats were slightly restless. The restlessness gradually disappeared and after one hour all rats were quiet.
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- It was concluded that the 4-hour LC50 of Chloramine T was higher than 275 mg/m3 air. This was the maximum attainable concentration in air. Therefore Chloramine T is not classified for acute inhalation toxicity.
- Executive summary:
The acute inhalation toxicity of Chloramine T was studied by exposing rats for 4-hours to a dust dispersion of the substance in air at a concentration of 275 mg/m3 air. This was the maximum attainable concentration in air. No mortality occurred and no signs of intoxication were observed. It was concluded that the 4-hour LC50 of Chloramine T was higher than 275 mg/m3 air.
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