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EC number: 451-530-8 | CAS number: 736150-63-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
TS-ED 532 is not irritatiing to skin, eyes and respiratory tract and shall not be classified according to GHS and DSD-DPD. TS-ED 532 was found to be not irritating after single topical semi-occlusive application to the skin of three rabbits of both sexes and after single instillation to the eyes of three rabbits of both sexes. Respiratory irritation is considered unlikely, because TS-ED 532 has a very low vapour pressure (1.1x10-7 Pa at 25 °C) .
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The application of TS-ED 532 to the skin of three rabbits resulted in moderate signs of irritation which included erythema and oedema. These effects were reversible and were no longer evident 7 days after treatment. TS-ED 532 caused no staining of the treated skin and no corrosive effects were observed. No clinical signs of TS-ED 532 related effects were observed. Overall, TS-ED 532 did not induce significant or irreversible damage to the skin. Hence, TS-ED 532 is considered to be not irritating to rabbit skin.
The instillation of TS-ED 532 into one eye of each of three rabbits resulted in mild, early-onset and transient ocular changes, such as reddening of the conjunctivae and sclerae, discharge and chemosis. These effects were reversible and no longer evident 48 h after instillation. No abnormal findings were observed in the cornea or iris. TS-ED 532 caused no staining of the treated eyes and no corrosive effects were observed. No clinical signs of TS-ED 532 related effects were observed. Overall, TS-ED 532 did not induce significant or irreversible damage to the rabbit eye. Hence, TS-ED 532 is considered to be not irritating to rabbit eye.
TS-ED 532 is a transparent liquid with a low vapour pressure of 1.1x10-7 Pa at 25 °C and 4.8x10-8 Pa at 20 °C. TS-ED 532 is therefore not volatile and respiratory irritation is considered unlikely.
Justification for classification or non-classification
TS-ED 532 was found to be not irritating after single topical semi-occlusive application to the skin of three rabbits of both sexes and after single instillation to one eye of each of three rabbits of both sexes. Based on these result, TS-ED 532 is not hazardous to skin and eyes and shall not be classified according to GHS and DSD-DPD.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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