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EC number: 947-618-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted April 13, 2004
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- HPLC analysis and UV/VIS-detection
- Details on sampling:
- Storage
Routinely, the samples were analysed immediately. Only in exceptional cases, they were stored overnight deep frozen and protected from light. - Vehicle:
- no
- Details on test solutions:
- Pre-treatment of test item and preparation of test item concentrations
To produce the only test item concentration, 100.2 mg of the test item was added to 1 litre of dilution water, treated for 1 h in an ultrasonic bath and stirred for 24 h on a magnetic stirrer. The pH was measured to be 7.8.
50 mL of the solution were taken and diluted with 0.5 mL of dilution water containing 5 daphnids resulting in a final concentration of 100 mg/L. For each test item concentration and the control 4 replicates were prepared. - Test organisms (species):
- Daphnia sp.
- Details on test organisms:
- Name : Daphnia magna STRAUS, parthenogenetic females
Source : Strain of Bundesgesundheitsamt Berlin
Maintenance and Acclimatisation : A population of parthenogenetic females of synchronized age structure has been maintained for more than 20 years in the test facility under constant temperature conditions (20 +/- 2 °C) at a 16 : 8 hour light-dark photoperiod (light intensity: < 20 μE x m-2 x s-1). The culture water (so-called 'M4 medium') was partly renewed once a week. The Daphnia were exclusively fed unicellular green algae (Desmodesmus subspicatus) 'ad libitum'. Mortalities of parent Daphnia during the culture period were recorded daily. The neonates were separated from their parent Daphnia by filtration prior to the acute test. - Test type:
- static
- Water media type:
- freshwater
- Remarks:
- Reconstituted water (so-called 'M4 medium' according to OECD 202 and EC Method C.2, annex 1) was used for the maintenance of the test animals and the preparation of stock and test solutions of the test item.
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 14.2 °dH (= 253 mg/L CaCO3)
- Test temperature:
- 18 - 22 °C (with a maximum temperature fluctuation of +/- 1 °C in each individual test)
- pH:
- 7.8 - 8.1
- Dissolved oxygen:
- 8.7 - 10.0 mg/L (95 - 101 %)
- Nominal and measured concentrations:
- 100 mg/L
- Details on test conditions:
- Preparation of 10 L M4-Medium
The medium is prepared weekly and is aerated until usage (stability: 1 week). To reduce bacteria growth the prepared Medium is cleaned by filtration and continuous ultraviolet radiation.
40 mL of solution 1.1 (CaCl2 solution)
10 mL of solution 1.2 (MgSO4 x 7H2O solution)
10 mL of solution 1.3 (KCl solution)
10 mL of solution 1.4 (NaHCO3 solution)
1 mL of solution 2.1 (cationic solution)
5 mL of solution 2.2 (anionic solution)
2 mL of solution 2.3 (silicate solution)
50 mL of solution 2.4 (ion/ EDTA solution)
5 mL of solution 2.5 (phosphate solution)
1 mL of solution 2.6 (vitamin solution)
Make up with deionized water to 10 L.
After aeration the pH value of the medium will be ca. pH 8.3 – 8.4. - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Immobilisation rates were recorded at 24-hour intervals. Additionally any abnormal behaviour or appearance of the Daphnia was reported every 24 hours.
- Reported statistics and error estimates:
- At a concentration of 100 mg/L no toxic effects against Daphnia were observed at the end of the 48 hour study period, thus no statistical analysis was required to determine the EC 50
- Validity criteria fulfilled:
- yes
- Remarks:
- The immobilisation and other abnormalities in the controls did not exceed 10 % by the end of the test. The dissolved oxygen concentration remained above 3 mg/L throughout the exposure period.
- Conclusions:
- An EC50 value of > 100 mg/L was determined after 48 h for EGGE 2806-1. No toxic effects against Daphnia were observed at a limit test concentration of 100 mg/L under exposure conditions.
- Executive summary:
A study was performed to assess the acute toxicity of EGGE 2806-1 to Daphnia magna STRAUS under static conditions. The study was following OECD Guideline for Testing of Chemicals No. 202 'Daphnia sp., Acute Immobilisation Test'. The Daphnia were exposed to a limit test concentration of nominally 100 mg/L of EGGE 2806-1 dissolved in dilution water. Observations were made on the swimming ability and the immobilisation rate, respectively, after 24 and 48 hours of exposure. An EC50 value of > 100 mg/L was determined after 48 h. No toxic effects against Daphnia were observed at a limit test concentration of 100 mg/L under exposure conditions.
The results are expressed in terms of nominal concentrations. .
Effective concentrations correspond to to 97.7% of nominal values at 48 hours.
Reference
Analysis
Nominal concentration |
HPLC value [mg/L] |
|
[mg/L] | at 0 hours | at 48 hours |
control | --- | < 0.858 |
100 | 100.701 | 97.707 |
Description of key information
A study was performed to assess the acute toxicity of EGGE 2806-1 to Daphnia magna STRAUS under static conditions. The study was following OECD Guideline for Testing of Chemicals No. 202 'Daphnia sp., Acute Immobilisation Test'. The Daphnia were exposed to a limit test concentration of nominally 100 mg/L of EGGE 2806-1 dissolved in dilution water. Observations were made on the swimming ability and the immobilisation rate, respectively, after 24 and 48 hours of exposure. An EC50 value of > 100 mg/L was determined after 48 h. No toxic effects against Daphnia were observed at a limit test concentration of 100 mg/L under exposure conditions.
The results are expressed in terms of nominal concentrations. .
Effective concentrations correspond to to 97.7% of nominal values at 48 hours.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Should read >100 mg/L.
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