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EC number: 246-045-1 | CAS number: 24157-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Alkylnaphthalenes. I. Absorption, Tissue Distribution and Excretion of 2,6-Diisopropylnaphthalene in Rats
- Author:
- Kojima S, Nakagawa M, Suzuki R, Horio M, and Tanaka Y
- Year:
- 1 978
- Bibliographic source:
- Chem Pharm Bull 26(10), 3007-3009,
- Report date:
- 1978
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- toxicokinetic study in rats; investigation of absorption, tissue distribution and elimination/excretions after oral administration of single doses
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6-diisopropylnaphthalene
- EC Number:
- 246-045-1
- EC Name:
- 2,6-diisopropylnaphthalene
- Cas Number:
- 24157-81-1
- Molecular formula:
- C16H20
- IUPAC Name:
- 2,6-diisopropylnaphthalene
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 230 - 270 g
- Individual metabolism cages: yes
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on exposure:
- 2,6-DIPN was administered as solution in olive oil (40 mg/mL)
- Duration and frequency of treatment / exposure:
- Administration of one single dose
Doses / concentrations
- Dose / conc.:
- 100 mg/kg bw/day (nominal)
- No. of animals per sex per dose / concentration:
- 3 to 5 animals
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, faeces, blood, liver, kidney, spleen, heart, brain, muscle, skin, adipose tissue
- Time and frequency of sampling: 2, 4, 6, 8, 14, 24, and 48 h after administration
- Other: rats were sacrificed at each designated time period by decapitation and the tissues collected
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled (delete / add / specify): urine, faeces, tissues, cage washes, bile
- Time and frequency of sampling:
- From how many animals: (samples pooled or not)
- Method type(s) for identification (e.g. GC-FID, GC-MS, HPLC-DAD, HPLC-MS-MS, HPLC-UV, Liquid scintillation counting, NMR, TLC)
- Limits of detection and quantification:
- Other:
TREATMENT FOR CLEAVAGE OF CONJUGATES (if applicable):
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- After a single dose, ca. 85 % of the dose administered was resorbed within 48 h. Maximal blood level were reached after ca. 2 h. The first-order rate constant for the gastrointestinal absorption of 2,6-DIPN was computed to be 0.170 per h. Overall, the gastrointestinal absorption of 2,6-DIPN appears to be considerably rapid.
- Details on distribution in tissues:
- Maximal levels of 2,6-DIPN in liver and kidney were reached after 2 h, as it was seen for the other tissues except skin and adipose tissue. Then 2,6-DIPN levels decreased with time. Maximum levels in skin and fat were reached after 10 hours and then levels decreased slowly. The highest maximum DIPN concentrations were found in adipose tissue followed in descending order by skin > liver > heart, kidney, brain > spleen > muscle.
Ca. 10 % (8 %) of the dose was transiently accumulated in adipose tissue after 10 h (24 h) p.a.
- Details on excretion:
- Excretion of unchanged 2,6-DIPN in feces amounted to ca 3.76 mg (about 15% of the dose) during 48 h. However, this fraction is not attributed to biliary excretion of ingested 2,6-DIPN.
Excretion of 2,6-DIPN in urine was marginal and most notable during the first 24 h.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: low bioaccumulation potential based on study results
After oral administration, 2,6-DIPN is resorbed by 85% within 48 h. The remainder is excreted in feces. Peak levels in blood and most tissues are reached within 2 h and largely eliminated after 24 h. In adipose tissue and skin, maximum levels are obtained 10 h p.a. Elimination is slow. After 10 and 24 h ca. 10 % and 8 %, respectively, of the dose are transiently accumulated in adipose tissue.
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