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EC number: 246-045-1 | CAS number: 24157-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For 2,6-DIPN the lipid normalized BCF values were determined as 810 (low dose group; 0.47 µg/L) and 2200 (high dose group; 4.85 µg/L), respectively.
Additional information
No bioaccumulation study concerning only 2,6-diisopropylnaphthalene (CAS 24157-81-1; 2,6-DIPN) was available. But a GLP study according to OECD 305 examining the bioaccumulative potential of Bis(isopropyl)naphthalene (DIPN), an isomeric mixture which consist of seven isomers (1,3-, 1,4-, 1,5-, 1,6-, 2,6- and 2,7-DIPN) is available and used in a read-across approach. In this study the BCF values of the seven isomers was determined individually for each isomer. The determined BCF values differed strongly between the isomers.
According to the recent OECD 305 (2012) as well as the ECHA Guidance Document R.11 (v2.0, 2014), the BCF values should be expressed based on a 5% lipid content. In the original study report the BCF data were not lipid-normalised. Therefore, in an expert statement by ECT Oekotoxikologie GmbH (ETC, 2017) a lipid-normalisation was performed using the data (BCF and lipid content) available in the original study report.
For 2,6-DIPN the lipid normalized BCF values were determined as 810 (low dose group; 0.47 µg/L) and 2200 (high dose group; 4.85 µg/L), respectively. Hence, 2,6-DIPN fulfils the criterion of being bioaccumulative (BCF > 2000) but not very bioaccumulative (BCF < 5000).
Although the environmental relevance of the results from the high exposure concentration is questionable (see expert statement ETC, 2017) the highest measured BCF value of 2200 was used as an worst case assumption for the bioaccumulation assessment. Therefore, 2,6-diisopropylnaphthalene (CAS24157-81-1) was assessed as bioaccumulative (B) but not very bioaccumulative (vB) under environmental conditions.
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