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EC number: 480-060-6 | CAS number: 24065-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Feb - 28 Feb 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Remarks:
- HPLC-UV
- Details on sampling:
- - Sampling method: Before, during and after the test period samples were taken and HPLC analysis were performed.
- Buffers:
- pH:4
buffer: citric acid / sodium hydroxide / sodium chloride, Riedel de Haen Art. No. 33643, ready to use solution
pH:7
buffer: potassium dihydrogen phosphate / Di-sodium hydrogen phosphate, Riedel de Haen Art. No. 33646, ready to use solution
pH: 9
buffer: borax / hydrochloric acid, Riedel de Haen Art. No. 33648, ready to use solution - Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Remarks:
- The initial nominal test concentration was 18 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Remarks:
- The initial nominal test concentration was 18 mg/L
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Remarks:
- The initial nominal test concentration was 18 mg/L
- Number of replicates:
- Three replicates
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- A preliminary study was performed and the results indicates that the test substance is hydrolytically stable at pH 4, pH 7, and pH 9 and no further study was performed.
- Transformation products:
- not measured
- % Recovery:
- 99.3
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 99.8
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 99.4
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Remarks:
- See 'Any other information on results incl. tables'
- Conclusions:
- The test substance is not degradable at pH 4, pH 7 and pH 9.
- Executive summary:
The study was performed to determine the hydrolysis of the test stubstance as a functon of pH according to EG guideline 92/69/EEC C.7. Solutions with a concentration of 0.11 mmol/L (18 mg/L) of the test substance in buffer soltuions with 1% solubilizer (acetonitrile) were tempered at 50°C for about 5 days. Results of preliminiary tests showed that within 5 days the degradation was less than 10% for the test substance at pH 4, pH 7 and pH 9. Based on the result the substance is considered hydrolytically stable at pH 4, pH 7, and pH 9.
Reference
Validity criteria for the hydrolysis study:
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
The analytical method used will depend on the nature of the substance and must be sufficiently precise and sensitive to detect a reduction of 10 % of the initial concentration. | Analysis via HPLC-UV is senstive enough to detect a reduction of 10% of the initial concentration. | Yes |
A sufficient number of samples (not less than four) should be chosen to cover the range 20 to 70 % of hydrolysis to test for pseudo-first order behaviour at the specified pH values. | pH 4 (50°C): 3 measurements pH 7 (50°C): 3 measurements pH 9 (50°C): 3 measurements The test substance is not degradable at pH 4, 7 and 9, therefore 3 measurements were sufficent to cover hydrolysis behavior. | Yes |
The method must be specific to allow determination of the test substance at the test solution concentrations and may well consist of some combination of suitable analytical techniques. | The test substance was determined by HPLC-UV detection at 250 nm. Chromatograms of the test and calibration solutions demonstrate the specificity of the method. | Yes |
Description of key information
A study was performed to determine the hydrolysis of the test stubstance as a functon of pH according to EG guideline 92/69/EEC C.7. Solutions with a concentration of 0.11 mmol/L (18 mg/L) of the test substance in buffer soltuions with 1% solubilizer (acetonitrile) were tempered at 50°C for about 5 days. Results of preliminiary tests showed that within 5 days the degradation was less than 10% for the test substance at pH 4, pH 7 and pH 9. Based on the result the substance is considered hydrolytically stable at pH 4, pH 7, and pH 9.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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