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EC number: 205-352-0 | CAS number: 139-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- appearance / physical state / colour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 22, 2007 to July 20, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Chemical name: C14 ADBAC
Lot/batch number: 612212
Expiry date: 21 December 2009
Percent active substance: 99.1%
Appearance: White powder
Storage conditions: Room temperature - Physical state at 20°C and 1013 hPa:
- solid
- Key result
- Form:
- solid
- Remarks:
- powder
- Colour:
- White
- Odour:
- ammonia-like
- Substance type:
- organic
- Conclusions:
- Under study conditions, the test substance was determined as white powder with an ammonia like odour.
- Executive summary:
A study was conducted to determine the appreance, physical state and odour of the test substance, C14 ADBAC, in compliance with GLP. The colour of test substance was determined under normal daylight, by the Munsell colour system, to be N 9.5/90.0% R (white) at 20°C and 101.3 kPa. The physical state of test substance was observed to be a white powder, while an odour was an ammonia-like at 20°C and 101.3 kPa (Sydney 2007).
The colour of test substance was determined under normal daylight, by the Munsell colour system, to be N 9.5/90.0% R (white) at 20°C and 101.3 kPa.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 22, 2007 to July 20, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Specific details on test material used for the study:
- Chemical name: C14 ADBAC
Lot/batch number: 612212
Expiry date: 21 December 2009
Percent active substance: 99.1%
Appearance: White powder
Storage conditions: Room temperature - Key result
- Test no.:
- #1
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 0 Pa
- Key result
- Test no.:
- #2
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 0 Pa
- Key result
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 0 Pa
- Remarks on result:
- other: Mean vapour pressure value
- Conclusions:
- Under study conditions, the mean vapour pressure of test substance was determined to be 1.8 × 10-4 Pa at 25ºC.
- Executive summary:
A study was conducted to determine the vapor pressure of the test substance, C14 ADBAC, according to the OECD Guideline 104 and EU Method A.4, in compliance with GLP. Under study conditions, the mean vapour pressure of test substance was determined to be 1.8 × 10-4 Pa at 25ºC (Sydney 2007).
Results:
Run 1 |
Run 2 |
|
Correlation: |
-0.9206 |
-0.9839 |
Slope: |
-6516 |
-5722 |
Intercept |
18.08 |
15.47 |
Vapour pressure (Pa) at 25ºC |
1.7 × 10 -4 |
1.9 × 10 -4 |
Mean vapour pressure value of 1.8 × 10 -4 Pa at 25ºC.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 19, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Laser scattering/diffraction and sieving
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- ca. 35.6 µm
- Geometric standard deviation:
- ca. 0.11
- Remarks on result:
- other: median particle size of the fine fraction
- Key result
- Percentile:
- D10
- Mean:
- ca. 10.8 µm
- St. dev.:
- 0.5
- Key result
- Percentile:
- D50
- Mean:
- ca. 35.6 µm
- St. dev.:
- 0.11
- Key result
- Percentile:
- D90
- Mean:
- ca. 106.5 µm
- St. dev.:
- 0.1
- No.:
- #1
- Size:
- < 250 µm
- Distribution:
- ca. 35.1 %
- No.:
- #2
- Size:
- < 200 µm
- Distribution:
- ca. 34.9 %
- No.:
- #3
- Size:
- < 100 µm
- Distribution:
- ca. 31 %
- No.:
- #4
- Size:
- < 50 µm
- Distribution:
- ca. 22.4 %
- No.:
- #5
- Size:
- < 10 µm
- Distribution:
- ca. 2.9 %
- Conclusions:
- Under the study conditions, the particle size distribution of the test substance was found to be: 65% > 2000 µm and 35% < 2000 µm (35%<250 µm; 35% of <200 µm; 31% <100 µm; 22.4% <50 µm), 2.9% < 10 µm. The median particle size (D50) of the fine particles were determined to be 36 µm.
- Executive summary:
A study was conducted to determine the particle size distribution of the test substance, C14 ADBAC, using laser scattering/diffraction method, according to the OECD Guideline 110, EPA OPPTS 830.7520 and ISO 13320, in compliance with GLP. Before the measurements, the test substance was sieved through a 2000 um sieve and the coarse fraction (with a particle size of >2000 µm) was found to be 64.9% and a fine fraction (with a particle size <2000 µm) was found to be 35.1%. The fine fraction was determined to have a median particle size D50 = 36 µm, which was determined by laser diffraction measurement. The mean D10, D50 and D90 (distribution type: volume) diameters applying the Fraunhofer particle model were determined to be 10.8, 35.6 and 106.5 µm respectively. According to the results of the laser diffraction measurement and the sieving, the test substance contains particles with a size of <250 µm of 35.1%, with a size of <200 µm of 34.9%, with a size of <100 µm of 31.0%, with a size of <50 µm of 22.4% with a size of <10 µm of 2.9%. Under the study conditions, the particle size distribution of the test substance was found to be: 65% > 2000 µm and 35% <2000 µm (35% <250 µm; 35% of <200 µm; 31% <100 µm; 22.4% <50 µm), 2.9% <10 µm. The median particle size (D50) was determined to be 36 µm (Moller, 2018).
According to R.7c Guidance, in humans, particles with aerodynamic diameters below 100 μm have the potential to be inhaled. Particles with aerodynamic diameters below 50 μm may reach the thoracic region and those below 15 μm the alveolar region of the respiratory tract. Therefore, based on the results of the study, about 90% of the substance, have a particle size >100 µm, hence are not available as inhalable fraction. Only around 8%, with a particle size <50 µm (median diameter of 36 µm), may reach the thoracic region and around 3%, may reach the alveolar region of the respiratory tract.
Results
Particle Size Distribution
Two test series of 3 measurements each were performed with the fine fraction of the test substance.
Test series 1:
D10: 11.2 µm
D50: 36.6 µm (Median diameter)
D90: 106.4 µm
Test series 2:
D10: 10.3 µm
D50: 34.5 µm (Median diameter)
D90: 106.5 µm
Average
D10: 10.8 µm
D50: 35.6 µm (Median diameter)
D90: 106.5 µm
Final Results
The test substance has a coarse fraction with a particle size of >2000 µm of 64.9 % and a fine fraction with a particle size <2000 µm of 35.1 %. The fine fraction has a median particle size D50 = 36 µm, which was determined by laser diffraction measurement. According to the results of the laser diffraction measurement and the sieving, the test substance contains particles with a size of <250 µm of 35.1 %, with a size of <200 µm of 34.9 %, with a size of <100 µm of 31.0 %, with a size of <50 µm of 22.4 % with a size of <10 µm of 2.9 %.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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