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EC number: 203-895-8 | CAS number: 111-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The method used permits the measurement of pH and acidic/alkaline reserve of all types of chemicals, under conditions which reproduce possible hydrolysis, in order to identify chemicals potentially corrosive to the eye.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Heptylamine
- EC Number:
- 203-895-8
- EC Name:
- Heptylamine
- Cas Number:
- 111-68-2
- Molecular formula:
- C7H17N
- IUPAC Name:
- heptan-1-amine
- Details on test material:
- - Name : n-heptylamine
- Purity: commertial grade
Constituent 1
Test system
- Details on study design:
- No guideline is available to assess the acidic/alkaline reserve of substances. However, the updated versions of guidelines 404 and 405 include a Supplement that recommends the sequential testing strategy (including pH and acidic/alkaline reserve measurements) prior to undertaking the in vivo tests for corrosion/irritation of the substance.
The method used in the present study to assess the pH and the acidic/alkaline reserve was described in the following references:
- JF. Regnier and C. Imbert (1992). Contributions of physical-chemical properties to the evaluation of ocular irritation. Third SPTC Meeting, ATLA 20, 457-465.
- V. Froment (1993). Stage report, Elf Atochem SA. Evaluation du potentiel corrosif des produits chimiques par deux méthodes alternatives au test de Draize : Corrositex, Méthode physico-chimique.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- other: pH
- Value:
- 11.7
- Remarks on result:
- other: Considered to be potentially corrosive, based on pH and alkaline reserve measurements
- Irritation parameter:
- other: alcaline reserve
- Value:
- 1.25
- Irritation parameter:
- other: Index
- Value:
- 12.9
Applicant's summary and conclusion
- Interpretation of results:
- other: Severely irritanting
- Conclusions:
- N-heptylamine is considered as potentially severely irritanting to the eye.
- Executive summary:
To evaluate the potential corrosivity for the eye of n-heptylamine, the pH and acidic/alkaline reserve was measured according to the method described by Regnier and Imbert (ATLA, 1992, 20, 457-465) and Froment (Arkema unpublished data, 1993). Under the test conditions, the results are as follow:
Test item
pH
log R (acidic/alkaline reserve
Physical-chemical index (I)
I = pH + log R, for pH =7
I = (14 -pH) + log R, for pH < 7
N-heptylamine
11.7
1.25
12.9
According to the method, a substance is considered as potentially corrosive to the eye if at least 2 of the 3 following criteria are fulfilled:
pH= 2.5 or pH =9.5; log R = 0 and /or I= 9.
N-heptylamine is considered as potentially severely irritanting to the eye.
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