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EC number: 203-895-8 | CAS number: 111-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion
This study evaluates the degrees of Cutaneous Primary Irritation and Corrosivity induced by the test article MONO-n-HEPTYLAMINE, in the albino rabbit, after a single application (Guillot, 1990).
A predetermined amount of the test article was applied once only to intact skin on the previously clipped back or one of the flanks of each rabbit of a same group. The MONO-n-HEPTYLAMINE is held in contact with the skin under a semi-occlusive patch for at least 4 consecutive hours. Then, the effects provoked 1, 24, 48 and 72 hours after the end of the contact period were observed, and a possible corrosive action of the test article was studied, characterised by the irreversibility of the lesions, by the observation of the animals over a longer period of time (Day 7 and Day 14 maximum).
The mean erythema score was 4 and the mean edema score was 2,67. Both were irreversible with superficial necrosis.
After a 4-hour dermal application, under semi-occlusive dressing, the test substance MONO-n-HEPTYLAMINE may be considered corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand Red
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bonen, 01400 Châtillon Sur Chalaronne, France
- Weight at study initiation: 2.3 kg
- Housing: individual housing, in polystyrene cages, of internal dimensions 560 x 355 x 315 mm, with a perforated floor.
- Diet: rabbit complete pelleted maintenance food, ad libitum
- Water: softened and filtered drinking water ad libitum
- Acclimation period: minimum of 5 days before the beginning of treatment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C.
- Humidity (%): 30 to 70%
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after the removal of the semi-occlusive patch and of the hydrophilic gauze pad, and days 7 and 14.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.4 cm square
- Type of wrap if used: crimped gauze bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): test article which had not penetrated was wiped away with a gauze pad moistened with distilled water (or a non-irritant solvant)
- Time after start of exposure: 4 hours - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24+48+72h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: superficial necrosis
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24+48+72h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- The test substance MONO-n-HEPTYLAMINE is corrosive
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- After a 4-hour dermal application, under semi-occlusive dressing, the test substance MONO-n-HEPTYLAMINE may be considered corrosive.
- Executive summary:
This study evaluates the degrees of Cutaneous Primary Irritation and Corrosivity induced by the test article MONO-n-HEPTYLAMINE, in the albino rabbit, after a single application.
A predetermined amount of the test article was applied once only to intact skin on the previously clipped back or one of the flanks of each rabbit of a same group. The MONO-n-HEPTYLAMINE is held in contact with the skin under a semi-occlusive patch for at least 4 consecutive hours. Then, the effects provoked 1, 24, 48 and 72 hours after the end of the contact period were observed, and a possible corrosive action of the test article was studied, characterised by the irreversibility of the lesions, by the observation of the animals over a longer period of time (Day 7 and Day 14 maximum).
The mean erythema score was 4 and the mean edema score was 2,67. Both were irreversible with superficial necrosis.
After a 4-hour dermal application, under semi-occlusive dressing, the test substance MONO-n-HEPTYLAMINE may be considered corrosive.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to CLP, the test substance MONO-n-HEPTYLAMINE should be considered classified corrosive 1C.
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