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Diss Factsheets
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EC number: 252-478-7 | CAS number: 35274-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- In general, the methodology was based on U. Tauber et al., Pharmacol. Skin, Volume 1, pp. 170-183.
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- sodium phosphate buffer
- Details on test conditions:
- Alkyl lactate was weighed (0.05-0.08 g) and dissolved in sodium phosphate buffer, pH 7.4, in 50 mL volumetric flasks. In the instance of the higher weight alkyl (S)-(S)-lactates, octyl, dodecyl, and octadecyl, they were weighed directly into the HPLC vial using a microbalance. A calculated amount of the dissolved alkyl lactate was pipetted into a 5 mL volumetric flask to which 1 mL of enzyme solution or buffer (as in the case of assessing chemical hydrolysis) was added. In the case of octyl, dodecyl, and octadecyl (S)-lactates, 0.8 mL of enzyme or buffer was added and then diluted with 3.2 mL of buffer for a total volume of 4 mL.
- Preliminary study:
- Not performed.
- Test performance:
- Not specified.
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- % Recovery:
- > 65 - <= 100
- pH:
- 7
- Temp.:
- 35
- Duration:
- ca. 6 h
- pH:
- 7
- Temp.:
- 35 °C
- DT50:
- > 24 h
- Type:
- (pseudo-)first order (= half-life)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Dodecyl lactate hydrolysed significantly during a six hour exposure period, whereas longer chain alkyl lactates (C16, C18) did not significantly hydrolyse during a period of 24 hours.
- Endpoint:
- hydrolysis
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. ANALOGUE APPROACH JUSTIFICATION
Since there is a significant relation between the analogues measured and the target substance, which only differs in chain length of the alcohol, read-across is here justified. - Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- no
- Preliminary study:
- Not performed.
- Test performance:
- Not specified.
- Transformation products:
- not specified
- Remarks on result:
- other: The C12 -14 alcohols have no hydrolysable structural features and would be expected to be stable in water. Oxidation would not be expected under normal environmental conditions.
- Conclusions:
- The C12 -14 alcohols have no hydrolysable structural features and would be expected to be stable in water. Oxidation would not be expected under normal environmental conditions.
Referenceopen allclose all
Based on the above study, short chain esters and in particular C8 esters hydrolyzed far more rapidly than large chain esters such as C16 and C18 esters. In fact, after 24 hour period, there was little to no hydrolysis observed for C16 and C18 esters.
Description of key information
Large chain esters such as cetyl lactate and long chain alcohols like hexadecanol appear to be hydrolytically stable.
Key value for chemical safety assessment
Additional information
Based on the reported study, short chain esters and in particular C8 esters hydrolyzed far more rapidly than large chain esters such as C16 and C18 esters. In fact, after 24 hour period, there was little to no hydrolysis observed for C16 and C18 esters.
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