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Diss Factsheets
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EC number: 205-771-9 | CAS number: 150-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No enough details. Documentation is insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
- Author:
- Hodge HC, Sterner JH, Maynard EA, Thomas J.
- Year:
- 1 949
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 31, 79-92.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other:
Test material
- Reference substance name:
- 1,4-dimethoxybenzene
- EC Number:
- 205-771-9
- EC Name:
- 1,4-dimethoxybenzene
- Cas Number:
- 150-78-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,4-dimethoxybenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Species: rat
- Strain: no data
- Sex: no data
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: Average weight of animals:
- group tested at 1000 mg: 175 g
- group tested at 1250 mg: 172 g
- group tested at 1500 mg: 176 g
- group tested at 1750 mg: 130 g.
- Fasting period before study: no data
- Housing: no data
- Food consumption: no data
- Water consumption: no data
- Acclimation period: no data
Environmental conditions: no data
In-life dates: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Maximum dose volume applied: 1750 mg
- Dosage preparation (if unusual): no data
- Rationale for the selection of the starting dose: no data - Doses:
- 1000; 1250; 1500; 1750 mg corresponding to 5714 mg/kg, 7267 mg/kg, 8522 mg/kg and 13461 mg/kg.
- No. of animals per sex per dose:
- for doses of 1000, 1250 and 1500 mg, 10 animals per dose.
For dose of 1750 mg, only one animal.
Sex unspecified. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- examinations performed: other: no data - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 500 mg/kg bw
- Mortality:
- 2/10 died at dose of 1000 mg (5714 mg/kg), whereas, 5/10 died at dose of 1500 mg (8522 mg/kg). One rat treated at dose of 1750 mg/kg, died.
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
The doses were not indicated in mg/kg bw but only in mg. The LD50 was calculated in accordance with weight of animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to EU and UN GHS criterias, the substance is not classified for acute oral toxicity.
- Executive summary:
In a oral acute study, rats were exposed to 5714 mg/kg, 7267 mg/kg, 8522 mg/kg and 13461 mg/kg of the test substance. The LD50 is 8500 mg/kg. Based on this value, the substance is not classified for acute oral toxicity.
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