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Diss Factsheets
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EC number: 205-771-9 | CAS number: 150-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test conditions, even if not in accordance with the recognised EC and OECD test guidelines, are sufficiently described to be validated. The GLP are not mentioned.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted to determine the sublethal effect of chemicals for an extended period (approx. 32d) on embryonic development, survival and growth of juvenile fish.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
No data - Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead minnow
- Strain: Pimephales promelas
- Source: no data
- Pre-exposure reproductive performance: not applicable
METHOD FOR PREPARATION AND COLLECTION OF FERTILIZED EGGS
- Numbers of parental fish (i.e. of females used to provide required number of eggs): no data
- Method of collection of fertilised eggs: no data
- Subsequent handling of eggs: fertilized eggs less than 24H old were incubated in glass-sided eggs cup with nylonscreen bottoms. Two egg cups were suspended in each aquarium. 30 eggs per cup were added in all tests. By a motor assembly, the eggs cup were slowly moved up and down in the water column a distance of approx. 5 cm. Upon completion of hatch (4-5 d), surviving fry were counted and 30 fry were released from the incubation cups into each aquarium.
POST-HATCH FEEDING
- Start date: 4-5 d
- Type/source of feed: Artemia and Tetramin
- Amount given: in equal volumes to each chamber (no more data)
- Frequency of feeding:fish were fed from the day after hatching to the end of each test (31-33 d) - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 33 d
- Post exposure observation period:
- no data
- Hardness:
- 45.2 (+/-2.0)
- Test temperature:
- 24.4 to 25.7°C (mean temperatures for the seven tested compounds)
- pH:
- 7.7 (+/-0.2)
- Dissolved oxygen:
- 65.2 to 78.6% of saturation (mean temperatures for the seven tested compounds)
- Nominal and measured concentrations:
- Measured concentrations : 7.16 (+/-1.27), 16.6 (+/-2.2), 27.4 (+/-2.94), 39.2 (+/-3.85), 60.4 (+/-5.6) mg/L.
- Details on test conditions:
- TEST SYSTEM
- Emybro cups (if used, type/material, size, fill volume): glass-sided eggs cup with nylon screen bottoms. Two egg cups were suspended in each aquarium.
- Test vessel:
- Type (delete if not applicable): open / closed: open
- Material, size, headspace, fill volume: 17.5 -L glass aquaria (20x35x25 cm), containing 4.5 to 4.9 liters of water
- Aeration: no data
- Type of flow-through (e.g. peristaltic or proportional diluter): water was delivered through one of two proportional diluter systems
- Renewal rate of test solution (frequency/flow rate): the diluter delivered 0.5 liters of water plus toxicant to each exposure chamber every 17.4 to 26.6 min.
- No. of fertilized eggs/embryos per vessel: 30
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates): none
- Biomass loading rate: no data
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Lake Superior water
- Alkalinity: 43.7 +/- 1.2, no other data
- Culture medium different from test medium: no
- Intervals of water quality measurement:no data
OTHER TEST CONDITIONS
- Adjustment of pH: no data
- Photoperiod: 16H light/8H dark
- Light intensity: artificial lighting was provided by fluorescent bulbs and intensities of 28+/-6 and 34+/- 7 ft-c at the water surfaces of the individual aquaria were measured.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Percent hatch, percent abnormal plus dead fry immediately after hatch, percent survival of transferred fry throughout the exposure period and length and weight of juvenile fish at the end of each exposure
VEHICLE CONTROL PERFORMED:no
RANGE-FINDING STUDY no data - Reference substance (positive control):
- not specified
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 16.6 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Hatchability, larval development, survival or growth in Fathead minnows.
- Duration:
- 33 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 27.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: significant reduction in wet weight and standard length
- Duration:
- 33 d
- Dose descriptor:
- other: MATC
- Effect conc.:
- 21.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Hatchability, larval development, survival or growth in Fathead minnows.
- Details on results:
- MATC: estimated maximum acceptable toxicant concentration determined as the geometric mean of NOEC ad LOEC.
Both wet weight and standard length were the most sensitive parameters with identical levels significance.
The percentage of newly hatched fry died or were malformed (percent dead plus abnormal) was affected at the two highest exposures (39.2 and 60.4 mg/L) of PDMB.
Fish survival was significantly reduced at the highest exposure (60.4 mg/L) of PDMB.
Whereas embryo hatchability was not different from controls. - Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- Data were analysed by one-way analysis of variance in conjunction with Dunnett's procedure.
- Validity criteria fulfilled:
- not specified
- Executive summary:
In a subchronic toxicity study, eggs and subsequent hatched fries of Pimephales promelas were exposed to Paradimethoxybenzene at doses from 0 to 60.4 mg/L in flow-through system during approximately 33 days.
A NOEC based on the hatchability, larval development, survival or growth in Pimephales promelas was determined to 16.6 mg/L .
A LOEC based on wet weight and standard length was determined to 27.4 mg/L.
Reference
Description of key information
Eggs of Pimephales promelas were exposed to Paradimethoxybenzene at doses from 0 to 60.4 mg/L.
The NOEC-33d was 16.6 mg/L based on the hatchability, larval development, survival or growth in Pimephales promelas.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 16.6 mg/L
Additional information
Only one study (Call et al., 1985) was available and was selected as key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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