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EC number: 259-943-3 | CAS number: 56011-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 22 February to 5 April 1982
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Oral intubation for 4 - 5 week old white mice.
Groups of mice were intubated at 3 dose levels using graded volumes of the test substance. Animals were observed for up to 7 days after the intubation. All animals dying were autopsied. All survivors were killed and examined post mortem after 7 days. - GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Isopentyl phenethyl ether
- EC Number:
- 259-943-3
- EC Name:
- Isopentyl phenethyl ether
- Cas Number:
- 56011-02-0
- Molecular formula:
- C13H20O
- IUPAC Name:
- isopentyl phenethyl ether
Constituent 1
- Specific details on test material used for the study:
- material name (as stated in the report): ANTHER
Appearance: Clear colourless liquid
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals are placed in individual cages, fasted for hours and then the animals were individually weighed.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals were intubated with the appropriate volumes of the test material. Each
- Doses:
- 10, 5 and 2 mg/Kg Body weight
- No. of animals per sex per dose:
- Each animal on one dosage level receives the same amount per Kg body weight.
- Control animals:
- no
- Details on study design:
- Groups of mice were intubated at 3 dose levels using graded volumes of the test substance. Animals were observed for up to 7 days after the intubation. All animals dying were autopsied. All survivors were killed and examined post mortem after 7 days.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 10 mg/Kg Body weight leads to 2 deaths (2 animals treated)
5 mg/Kg Body weight leads to 3 deaths (6 animals treated)
2 mg/Kg Body weight leads to 0 death (2 animals treated) - Clinical signs:
- other: 10 and 5 mg/Kg Body weight : signs of stress, somnolent, hypothermy and laboured breating
Any other information on results incl. tables
All mice dosed at 10 and 5 mg/Kg Body weight were showing signs of stress within 1 hour after treatment. The mice dosed at 10 mg/Kg bw became somnolent and died within 18 hours.
The mice dosed at 5 mg/Kg Body weight also became somnolent and two mice died within 18 hours. At this time, these mice were hypothermic and showing laboured breathing and one more mouse died within 90 hours. The surviving mice recovered within 48 hours.
The mice dosed at 2 mg/Kg bw appeared unaffected by the treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 (oral) of ANTHER was determined to be 5000 mg/Kg Body weight according to this test. Therefore it can be concluded that the test substance ANTHER does not meet the criteria to be classified according to the CLP Regulation 1272/2008/EC.
- Executive summary:
The LD50 (oral) of Anther was determined in this Acute Oral Toxicity Test dated on 4 April 1982, performed at Unilever research Laboratory.
Groups of mice were intubated at 3 dose levels using graded volumes of the test substance. Animals were observed for up to 7 days after intubation. All animals dying were autopsied. All survivors were killed and examined post mortem after 7 days.
All mice dosed at 10 and 5 mg/Kg Body weight were showing signs of stress within 1 hour after treatment. The mice dosed at 10 mg/Kg bw became somnolent and died within 18 hours.
The mice dosed at 5 mg/Kg Body weight also became somnolent and two mice died within 18 hours. At this time, these mice were hypothermic and showing laboured breathing and one more mouse died within 90 hours. The surviving mice recovered within 48 hours. The mice dosed at 2 mg/Kg bw appeared unaffected by the treatment. The LD50 (oral) of ANTHER was determined to be 5000 mg/Kg Body weight according to this test. Therefore it can be concluded that the test substance ANTHER does not meet the criteria to be classified according to the CLP Regulation 1272/2008/EC, but does according to GHS criteria (Cat.5.) based on 3 out of 6 animals dying at 5 g/kg.
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