Registration Dossier
Registration Dossier
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EC number: 204-234-6 | CAS number: 118-10-5
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.011 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.114 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 4.52 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.452 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 4.52 mg/kg soil dw
Hazard for predators
Additional information
Cinchonine hydrochloride was tested in astatic Daphnia magna, Acute Immobilisation Test according to the OECD Guideline 202 for 48 h. Five nominal concentrations between 6.25 and 100 mg/L were used. The EC50 of cinchonine hydrochloride is 79.96 mg/L for Daphnia magna during the test period of 24 h. And the EC50 during the test period of 48 h is 14.25 mg/L. According to this, the EC50 of cinchonine is 11.41 mg/L.
Conclusion on classification
The experimentally determined EC50 of cinchonine for invertebrates is > 10 mg/L. According to CLP 1272/2008 criteria for acute aquatic toxicity, cinchonine does not need to be classified.
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