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EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 October 2005 to 16 November 2005
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- EC Number:
- 255-255-2
- EC Name:
- O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
- Cas Number:
- 41198-08-7
- Molecular formula:
- C11H15BrClO3PS
- IUPAC Name:
- 4-bromo-2-chlorophenyl ethyl (propylsulfanyl)phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 350, 1100 mg/kg
- No. of animals per sex per dose:
- 5/gp
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 620.5 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 350 - ca. 1 100
Any other information on results incl. tables
Individual bodyweights/weight gains and mortality are presented in Table 1, Individual cage-side observations and necropsy observations are presented in Tables 2 and 3, respectively.
350 mg/kg (3 animals)
All animals survived, appeared active and healthy and gained body weight over the 14-day observation period. There were no signs of gross toxicity, adverse pharmacologic effect or abnormal behavior. No gross abnormalities were noted for either animal when necropsied following the 14-day observation period.
1,100 mg/kg (3 animals)
All animals died within two days of test substance administration. Toxic signs noted prior to death included ocular discharge, hypoactivity, abnormal posture, piloerection, ano-genital staining and a reduced fecal volume. Gross necropsy of the decedents revealed discoloration of the intestines.
Table 7.2.1 -2: Individual body weights/weight gains doses and mortalities
Animal No. |
Sex |
Dose Level (mg/kg) |
Body Weight (g) |
Dose (mL) |
Mortality |
|||||
Day 0 Weight |
Day 7 Weight |
Gain* |
Day 14 Weight |
Gain* |
Day |
Weight (g) |
||||
6099 |
F |
350 |
200 |
218 |
18 |
247 |
47 |
0.048 |
E |
- |
6220 |
F |
215 |
227 |
12 |
249 |
34 |
0.052 |
E |
- |
|
6372 |
F |
223 |
234 |
11 |
282 |
59 |
0.054 |
E |
- |
|
6108 |
F |
1,100 |
185 |
- |
- |
- |
- |
- |
1 |
176 |
6261 |
F |
219 |
- |
- |
- |
- |
0.16 |
2 |
201 |
|
6384 |
F |
225 |
- |
- |
- |
- |
0.17 |
1 |
219 |
Table 7.2.1 -3: Individual cage side observations
Animal Number |
Findings |
Day of Occurrence |
350 mg/kg |
||
6099 |
Active and healthy |
0-14 |
6220 |
||
6372 |
||
1100 mg/kg |
||
6108 |
Active and healthy Hypoactive Ocular discharge (clear), hunched posture Dead |
0 (1 hr) 0 (3-6 hrs) 0 (6 hrs) 1 |
6261 |
Active and healthy Hypoactive Ano-genital staining, reduced faecal volume Prone posture Dead |
0 (1 hr) 0 (3 hrs)-1 1
1 2 |
6384 |
Active and healthy Hypoactive Hunched posture, piloerection) Dead |
0 (1 hr) 0 (3-7 hrs) 0 (7 hrs) 1 |
Table 7.2.1 -4: Individual necropsy observations
Animal Number
|
Tissue |
Findings |
350 mg/kg |
||
6099, 6220, 6372 |
All tissues and organs |
No gross abnormalities |
1100 mg/kg |
||
6108, 6261, 6384 |
Intestines |
Red |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of Profenofos Technical is estimated to be 620.5 mg/kg of body weight in female rats with an approximate 95% Confidence Interval of 350 mg/kg (lower) to 1,100 mg/kg (upper).
- Executive summary:
An acute oral toxicity test (Up and Down Procedure) was conducted with rats to determine the potential for Profenofos Technical to produce toxicity from a single dose via the oral route.
Based on an estimate of the LD50 supplied by the Sponsor (1,100 mg/kg), an initial dose of 350 mg/kg was administered to one healthy female rat by oral gavage. Following the Up and Down procedure, five additional females were tested at levels of 350 or 1,100 mg/kg. Females were selected for the test because they are frequently more sensitive to the toxicity of test compounds than males. All animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days after dosing or until death occurred. Body weights were recorded prior to administration and again on Days 7 and 14 (termination) following dosing or after death. Necropsies were performed on all animals.
Under the conditions of this study, the acute oral LD50 of Profenofos Technical is estimated to be 620.5 mg/kg of body weight in female rats with an approximate 95% Confidence Interval of 350 mg/kg (lower) to 1,100 mg/kg (upper).
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