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EC number: 206-992-3 | CAS number: 420-04-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-12-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Type:
- Pow
- Partition coefficient:
- 0.19
- Temp.:
- 20 °C
- pH:
- 6.8
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.72
- Temp.:
- 20 °C
- pH:
- 6.8
- Details on results:
- The detector calibration for the UV analysis was found to be a curve over the range 1.0 to 25.7 mg/L of standard solutions hence a polynominal regression was applied.
The mean recoveries of Cyanamid F1000 from the method verification samples were as follows: Cyanamid F1000 in n-octanol and in water showed a recovery of 101 % and a RSD (n = 4) of 10.5 and 1.1, respectively. These results indicate that the analytical methods were accurate in the quantification of the test substance in both n-octanol and water. Results of the test showed a measured Pow value of 0.2 (logPow = 0.70). - Conclusions:
- The (mean) octanol/water partition coefficient of Cyanamid F1000 was found to be 0.19 ± 0.01 (mean log10Pow = -0.72 ± 0.02) at 20 °C.
- Executive summary:
An experimental study was conducted to determine the partition coefficient (octanol-water) of Cyanamid F1000. The test was performed using the shake flask method at 20 °C, according to the OECD Guideline 107 and the EU Method A.8. The octanol/water partition coefficient, Pow, of Cyanamid F1000 was determined to be 0.19 ± 0.01 (log Pow = -0.72 ± 0.02) at 20 °C.
Reference
Determination of the partition coefficient of Cyanamid F1000 between n-octanol and water
Sample | A | B | C | D | E | F |
n-octanol volume (mL) | 15 | 15 | 20 | 20 | 10 | 10 |
Cyanamid F1000 in n-octanol (mg/L) | 33.45 | 32.07 | 57.12 | 59.59 | 19.26 | 24.75 |
Total Cyanamid F1000 in n-octanol (mg) | 502 | 481 | 1140 | 1190 | 193 | 248 |
Water volume (mL) | 15 | 15 | 10 | 10 | 20 | 20 |
Cyanamid F1000 in water (mg/L) | 179.7 | 175.8 | 311.1 | 301.6 | 94.88 | 95.61 |
Total Cyanamid F1000 in water (μg) | 2700 | 2640 | 3110 | 3020 | 1900 | 1910 |
Total Cyanamid F1000 added (μg) | 3440 | 3440 | 4580 | 4580 | 2290 | 2290 |
Total Cyanamid F1000 recovered (μg) | 3200 | 3120 | 4250 | 4210 | 2090 | 2160 |
pH of water phase after partition | 6.8 | 6.7 | 6.8 | 6.9 | 6.8 | 6.8 |
Pow | 0.186 | 0.182 | 0.184 | 0.198 | 0.203 | 0.259* |
Log10Pow | -0.730 | -0.739 | -0.736 | -0.704 | -0.693 | -0.587* |
* value not included in the mean calculations as it is considered to be outlier under the Dixon criterion, at the 5 % significance level.
Mean Pow=0.19
Standard deviation = 0.01
Mean log10Pow= -0.72
Standard deviation = 0.02
Description of key information
The octanol/water partition coefficient, Pow, of Cyanamid F1000 was determined to be 0.19 ± 0.01 (log Pow = -0.72 ± 0.02) at 20 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.72
- at the temperature of:
- 20 °C
Additional information
An experimental study was conducted to determine the partition coefficient (octanol-water) of Cyanamid F1000. The test was performed using the shake flask method at 20 °C, according to the OECD Guideline 107 and the EU Method A.8. The octanol/water partition coefficient, Pow, of Cyanamid F1000 was determined to be 0.19 ± 0.01 (log Pow = -0.72 ± 0.02) at 20 °C.
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