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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-12-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
0.19
Temp.:
20 °C
pH:
6.8
Key result
Type:
log Pow
Partition coefficient:
-0.72
Temp.:
20 °C
pH:
6.8
Details on results:
The detector calibration for the UV analysis was found to be a curve over the range 1.0 to 25.7 mg/L of standard solutions hence a polynominal regression was applied.
The mean recoveries of Cyanamid F1000 from the method verification samples were as follows: Cyanamid F1000 in n-octanol and in water showed a recovery of 101 % and a RSD (n = 4) of 10.5 and 1.1, respectively. These results indicate that the analytical methods were accurate in the quantification of the test substance in both n-octanol and water. Results of the test showed a measured Pow value of 0.2 (logPow = 0.70).

 


Determination of the partition coefficient of Cyanamid F1000 between n-octanol and water


 


















































































































Sample



A



B



C



D



E



F



n-octanol volume (mL)



15



15



20



20



10



10



Cyanamid F1000 in n-octanol (mg/L)



33.45



32.07



57.12



59.59



19.26



24.75



Total Cyanamid F1000 in n-octanol (mg)



502



481



1140



1190



193



248



Water volume (mL)



15



15



10



10



20



20



Cyanamid F1000 in water (mg/L)



179.7



175.8



311.1



301.6



94.88



95.61



Total Cyanamid F1000 in water (μg)



2700



2640



3110



3020



1900



1910



Total Cyanamid F1000 added (μg)



3440



3440



4580



4580



2290



2290



Total Cyanamid F1000 recovered (μg)



3200



3120



4250



4210



2090



2160



pH of water phase after partition



6.8



6.7



6.8



6.9



6.8



6.8



Pow



0.186



0.182



0.184



0.198



0.203



0.259*



Log10Pow



-0.730



-0.739



-0.736



-0.704



-0.693



-0.587*



* value not included in the mean calculations as it is considered to be outlier under the Dixon criterion, at the 5 % significance level.


 Mean Pow=0.19


Standard deviation = 0.01


 Mean log10Pow= -0.72


Standard deviation = 0.02

Conclusions:
The (mean) octanol/water partition coefficient of Cyanamid F1000 was found to be 0.19 ± 0.01 (mean log10Pow = -0.72 ± 0.02) at 20 °C.
Executive summary:

An experimental study was conducted to determine the partition coefficient (octanol-water) of Cyanamid F1000. The test was performed using the shake flask method at 20 °C, according to the OECD Guideline 107 and the EU Method A.8. The octanol/water partition coefficient, Pow, of Cyanamid F1000 was determined to be 0.19 ± 0.01 (log Pow = -0.72 ± 0.02) at 20 °C.

Description of key information

The octanol/water partition coefficient, Pow, of Cyanamid F1000 was determined to be 0.19 ± 0.01 (log Pow = -0.72 ± 0.02) at 20 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.72
at the temperature of:
20 °C

Additional information

An experimental study was conducted to determine the partition coefficient (octanol-water) of Cyanamid F1000. The test was performed using the shake flask method at 20 °C, according to the OECD Guideline 107 and the EU Method A.8. The octanol/water partition coefficient, Pow, of Cyanamid F1000 was determined to be 0.19 ± 0.01 (log Pow = -0.72 ± 0.02) at 20 °C.