Registration Dossier
Registration Dossier
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EC number: 218-690-9 | CAS number: 2216-51-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The bioaccumulation of menthols in fish (Cyprinus carpio) was determined in a test according to standard method built by Japanese competent authority. The BCF was determined to be 0.5-15. It can be concluded from the test that the substance menthol has no bioaccumulation potential.
Key value for chemical safety assessment
- BCF (aquatic species):
- 15 dimensionless
Additional information
The bioaccumulation of DL-menthol in fish (Cyprinus carpio) was determined in a test according to standard method built by Japanese competent authority, and which is equivalent or similar to OECD guideline 305 C. Since the property of BCF was mostly related to the molecular size and lipid solubility, the isomers mostly have similar bioaccumulation potential. Therefore, although the test substance in the report is DL-menthol (mixture of D-&L enantiomers), it can be considered as important information for L-menthol bioaccumulation potential.
A more detailed read-across justification is found in the Read-across justification for Menthols (see MentholsReadAcrossFinal.pdf) in section 13). BCFs in the range of 0.5 - 15 L/kg with 0.2 mg menthol/L resp. 4.6 - 11 L/kg with 0.02 mg menthol/L were reported indicating no significant bioaccumulation potential. The variation of results may be partially explained by the variation of the lipid content in fish (2 - 6 %). To the worst case, the BCF of L-menthol for fish was selected as 15.
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