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Diss Factsheets
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EC number: 203-943-8 | CAS number: 112-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: reproduction/development
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 09/1994-02/1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD and it is GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- Molecular formula:
- C14H31N
- IUPAC Name:
- dodecyldimethylamine
- Details on test material:
- - Physical state: clear liquid
- Storage: at room temperature
- Stability: stable for the duration of the study
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test species: Rat/Sprague-Dawley Crl
Source: Charles River Deutschlanf GmbH
Animals: Five groups of 10 male and 10 female rats each
Body weight: males: 313-340g and female: 216-242g
Age: 69-72 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil, DAB 10
- Details on exposure:
- Administration volume: 2 mL/kg b.w. /day
Dose-levels: Group 1: control (vehicle), Group 2: 50mg, Group 3: 150mg, Group: 300mg, Group:450mg (10 males / 10 females) - Details on mating procedure:
- Mating was monogamous: 1 male and 1 female animal were placed together in one cage during the dark period.
Each morning the female were examined for the presence of sperm. If findings were negative, mating was repeated. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Males: 14 days prior to mating and during the 14-day mating period
Female: 14 days prior to mating and during the mating period, pregnancy and lactation period. - Frequency of treatment:
- administered orally at a constant volume of 2 mL/kg b.w/dya on 7 days per week during the following periods:
males: two weeks orior to mating period and approx. 2 weeks post mating at least until the minimum total dosing period of 28 days had been completed.
females: throughout the study beginning two weeks prior to mating and continuing uo to, and including, day 3 post partum or the day before sacrifice. - Details on study schedule:
- 1 adaptation week and approx. 54 test days [14 days premating, (up to) 14 days mating, 22 days gestation. 4 days lactation]
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 150, 300 and 450 mg/kg b.w./day
Basis:
nominal conc.
- No. of animals per sex per dose:
- control, low dose, low intermediate dose, high intermediate dose and hich dose [ 10 males / 10 females] for all doses
- Control animals:
- yes
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Sex:
- male/female
- Remarks on result:
- other: Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Under the present test conditions the no-observed-effect level (NOEL) for both parent animals and their pups was 50 mg Dodecyldimethylamine / kg b.w./day, by gavage in a reproduction / devolopment toxicity screening test with rats.
150 mg/kg b.w./day were in the beginning lethal range for pregnant rats and in the toxic range for embryos/fetuses/pups.
Only one dam of the group treated with 300 mg/kg b.w./day delivered one female pup alive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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