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EC number: 203-943-8 | CAS number: 112-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
ACUTE TOXICITY
In a reliable 14-day acute toxicity study (reliability category 1) with C12-14 DMA on Eisenia fetida, no signs of toxicity were observed at the nominal limit concentration of 1000 mg/kg soil dry weight.
CHRONIC TOXICITY
In a reliable study (reliability category 1) assessing effects of the supporting substance HYEQS on mortality, biomass and the reproductive potential of the earthworm species Eisenia fetida, a NOEC (reproduction, 56 d) of 125 mg/kg soil dry weight was determined. No other adverse effects were observed.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 125 mg/kg soil dw
Additional information
ACUTE TOXICITY
C12-14 DMA was tested for acute toxicity on Eisenia fetida in a reliable acute toxicity study (reliability category 1) according to OECD 207 performed compliant to GLP. The study was conducted with a limit test item concentration of 1000 mg/kg soil dry weight throughout 14 days. 40 test organisms with an individual weight between 0.3 - 0.6 g, divided into four replicates, were tested in regard to mortality, pathological symptoms, biomass and changes in the earthworm behaviour. No effects in regard to any of the investigated endpoints could be observed.
Consequently, DMA category members may be regarded as acutely non-toxic to terrestrial macroorganisms.
CHRONIC TOXICITY
Chronic toxicity of the supporting substance HYEQS to the earthworm species Eisenia fetida was assessed in a reliable (category 1) Earthworm Reproduction test performed according to OECD 222 (2004) and compliant to GLP over a period of 8 weeks.
HYEQS is of high similarity to C12-14 DMA in that it has essentially the same alkyl chain distribution and – like DMA category members - two methyl substituents at the amino group. The only difference is an additional hydroxyethyl substituent at the amino group rendering it a quaternary amine being permanently positively charged. This is however a minor difference as due to protonation at environmentally relevant pH values also DMA category members are predominantly positively charged at the amino group.
HYEQS was tested at five different application rates between 62.5 and 1000 mg/kg soil dry weight. Sexually mature earthworms were inserted into 6 control replicates and into 4 replicates per test item concentration (10 earthworms per replicate). The earthworms had an individual body weight ranging between 0.30 and 0.60 g at test initiation. HYEQS did not induce mortality or pathological symptoms to adult earthworms and the biomass increase of the adult earthworms was not statistically significantly reduced compared to the control after 28 days exposure. After eight weeks of exposure, the earthworm reproduction was statistically significantly reduced at 250 mg HYEQS /kg soil dry weight and higher compared to the control. All validity criteria of the OECD-guideline were met. Therefore,the following no-effect concentration for terrestrial macro-organisms is regarded as relevant for DMA category members: NOEC (56d; E. fetida; reproduction) = 125 mg/kg soil dry weight
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