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Diss Factsheets
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EC number: 221-201-1 | CAS number: 3030-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions - limited description of test animals - observation duration of 8 days only
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (limited documentation, observation duration of only 8 days)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Bis(2-dimethylaminoethyl)(methyl)amine
- EC Number:
- 221-201-1
- EC Name:
- Bis(2-dimethylaminoethyl)(methyl)amine
- Cas Number:
- 3030-47-5
- Molecular formula:
- C9H23N3
- IUPAC Name:
- (2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl)dimethylamine
- Details on test material:
- - Name of test substance (as cited in study report): Pentamethyl-diaethylen-trieamin
- Analytical purity: no data
- Physical state: liquid
- Density: 0.829 g/cm³
- Substance number: XXIII/80
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Gassner
- Mean weight at study initiation: 192.5 g (males); 181.5 g (females)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30%, 16%, 8% and 2% (v/v)
MAXIMUM DOSE VOLUME APPLIED: ca. 10.6 mL/kg bw - Doses:
- 3200, 1600, 800 and 200 µL/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations: daily
- Frequency of weighing: doumentation on day 0
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 330 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 663 - < 2 653
- Remarks on result:
- other: Corresponds to ca. 1600 µL/kg bw; Conversion based on a density of 0.829 mg/cm³.
- Mortality:
- - 3200 µL/kg bw: 10/10 animals died within 24 h after application.
- 1600 µL/kg bw: 4/10 animals died within 8 days after application (1 male within 8 days, 1 female within 24 h and 2 more females within the following 24 h after application)
- 800 and 200 µL/kg bw: 0/10 animals died - Clinical signs:
- other: - 3200 µL/kg bw: increased respiration (immediately after application); abdominal position (few minutes after application); crouched position, irregular respiration and slight apathy (few hours after application); crouched position, increased respiration
- Gross pathology:
- - Animals that died: general hyperaemia, heart dilatation, hydrothorax, grey-brown liver, liquid content of intestine, edema of glandular stomach, dilated ecchymosis, injected stomach vessels, diarrhoeic content of intestine.
- Sacrificed animals: no abnormalities
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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