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EC number: 246-356-2 | CAS number: 24613-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 February to 04 March 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Proprietary GLP guideline-compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dichromium tris(chromate)
- EC Number:
- 246-356-2
- EC Name:
- Dichromium tris(chromate)
- Cas Number:
- 24613-89-6
- Molecular formula:
- CrH2O4.2/3Cr
- IUPAC Name:
- dichromium tris(chromate)
- Test material form:
- other: solution
- Details on test material:
- The test material was dichromium tris(chromate) 25% solution, batch no. RCAJ29F1TOX, described as a dark brown liquid. The batch had an expiry date of November 2010, and was stored at room temperature.
All concentrations were expressed as active ingredient.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were young adult male/female CRL:(WI) BR SPF rats, obtained from TOXI-COOP Ltd (Budapest). At the start of the study the females were 7-8 weeks old and the males were 6-7 weeks, the weight range at dosing was 200-251 g. Females were nulliparous and non-pregnant. The rats were acclimatised for 6-8 days. Only healthy animals (veterinary surgeon certified) were used for the study.
Rats were individually housed in Type II polypropylene/polycarbonate cages with Lignocel Bedding (a copy of the certificate of analysis was retained by the test facility). The temperature in the animal room was 22±3°C, relative humidty was 30-70%, there were 15-20 air changes per hour and light was provided for 12 hours daily.
Animals were fed ssniff SM R/M-Z+H "Autoclavable complete feed for rats and mice - breeding and maintenance" (ssniff Spezialdiaten GmbH, Germany) ad libitum. Tap water from the municipal supply was provided ad libitum.
Individuals were identified by indelible ink markings on the tail.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Doses of 175, 350 and 850 mg active ingredient/kg bw (equivalent to 741, 1483 and 3602 mg/kg of 25% solution) were tested initially. Two days later additional doses of 1400 and 2000 mg active ingredient/kg bw (equivalent to 5932 and 8475 mg/kg of 25% solution) were chosen after discussion with the sponsor. A preliminary study was performed to identify appropriate dose ranges.
The test material was applied as supplied.
An area of approximately 10% of the total body surface on the back of each animal was shaved approximately 24 hours prior to treatment. The test item was applied as a single dose, and was held in contact with the skin for 24 hours using sterile gauze pads covered with adhesive hypoallergenic plaster. The entire trunk of the animal was then wrapped with a semi-occlusive plastic wrap. After 24 hours the wrappings were removed and the test site was washed with water at body temperature. - Duration of exposure:
- 24 hours
- Doses:
- 175, 350, 850, 1400 and 2000 mg active ingredient/kg bw.
- No. of animals per sex per dose:
- 1 rat/sex/dose
- Control animals:
- not required
- Details on study design:
- Clinical observations were made at 1 and 5 hours after application of the test material, and once daily thereafter for 14 days. Observations were made of the skin, fur, eyes, mucous membranes, the respiratory, circulatory, autonomic and central nervous system, somatomotor activity and behaviour pattern. Particular attention was given to observation of tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma.
Body weights were recorded immediately before test item administration (day 0), and on days 7 and 14.
Gross necropsy was performed on all animals. Animals were euthanised by exsanguination under pentobarbital anaesthesia. The rats were examined externally, then the cranial, thoracic and abdominal cavities were opened and the tissues and organs examined macroscopically. - Statistics:
- Not required.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortalities occurred.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- The only macroscopic findings were dark/brown discolouration of the fur at the dosing site in 1/2, 2/2 and 2/2 animals at dose levels of 850, 1400 and 2000 mg/kg, respectively.
- Other findings:
- Brownish staining of the hair and skin was observed from Day 1 up to Day 8 in 6 animals. Brownish staining of the hair was observed from Day 9 to 14 in five animals. No local signs of skin aleration were observed during the observation period.
Any other information on results incl. tables
No further information.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of Dichromium tris(chromate), tested as a water solution (23.6% active ingredient) was found to be >2000 mg active ingredient/kg bw in male and female rats.
- Executive summary:
The acute dermal toxicity of Dichromium tris(chromate) water solution (23.6% active ingredient) was evaluated in male and female CRL:(WI) BR rats, according to OECD 402. The test material was applied to the shaved dorsal skin of 1 male and 1 female rat per dose, and held in place using a semi-occlusive dressing for 24 hours. Dose levels applied, expressed in terms of active ingredient, were; 175, 350, 850, 1400 and 2000 mg/kg bw. The rats were observed for 14 days following removal of the dressings, and were necropsied at the end of the observation period.
There were no mortalities, no clinical signs were observed, no abnormalities were detected at necropsy, and no local effects on skin reported. Brownish staining of the hair and skin was observed from Day 1 up to Day 8 in 6 animals, and brownish staining of the hair was observed from Day 9 to 14 in 5 animals. Discolouration of the hair at the test site was also noted at necropsy in rats at dose levels 850, 1400 and 2000 mg active ingredient/kg.
It was concluded that the acute dermal LD50 of Dichromium tris(chromate) is greater than 2000 mg/kg bw in male and female CRL:(WI) rats.
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