Registration Dossier
Registration Dossier
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EC number: 200-812-7 | CAS number: 74-82-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, TGD guideline, QSAR calculation, reliable with restrictions
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Computer model
- Title:
- The Estimation Programs Interface (EPI) SuiteTM v4.00
- Author:
- US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC)
- Year:
- 2 009
- Bibliographic source:
- USEPA OPPT Risk Assessment Division
Materials and methods
- Principles of method if other than guideline:
- The Ecosar class program has been developed primarily for the evaluation of neutral organic compounds and organic classes with excess toxicity. The QSARs in the Ecosar program are developed for chemical classes based on measured test data that have been submitted by industry or they are developed by other sources for chemicals with similar structures, e.g. phenols. Using the measured aquatic toxicity values and estimated Kow values, regression equations can be developed for a class of chemicals. Toxicity values for new chemicals may then be calculated by inserting the Kow into the regression equation and correcting the resultant value for the molecular weight of the compound.
- GLP compliance:
- no
- Remarks:
- Not applicable
Test material
- Reference substance name:
- Reference substance 003
- Cas Number:
- 74-82-8
- Molecular formula:
- C H4
- Details on test material:
- No data reported
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data reported
Sampling and analysis
- Analytical monitoring:
- not specified
- Details on sampling:
- No data reported
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- No data reported
Test organisms
- Test organisms (species):
- Daphnia sp.
- Details on test organisms:
- No data reported
Study design
- Test type:
- other: Not applicable
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No data reported
Test conditions
- Hardness:
- No data reported
- Test temperature:
- No data reported
- pH:
- No data reported
- Dissolved oxygen:
- No data reported
- Salinity:
- No data reported
- Nominal and measured concentrations:
- No data reported
- Details on test conditions:
- No data reported
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 69.43 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Details on results:
- The result is above the water solubility of methane.
- Results with reference substance (positive control):
- No data reported
- Reported statistics and error estimates:
- No data reported
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Remarks:
- QSAR
- Conclusions:
- The calculated 48 hour LC50 for methane is 69.43 mg/L. The result is above the water solubility of methane.
- Executive summary:
No experimental data are available for the effect of methane on the short term toxicity of aquatic invertebrates so QSAR calculations were used to estimate result. ECOSAR Program v1.00. in EPI Suite v4.00 has been used which is acceptable with restrictions. The 48 hour LC50 for Daphnia is estimated to be 69.43 mg/L in fresh water. The result is above the water solubility of methane.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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