Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, TGD guideline, QSAR calculation, acceptable with restriction
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
review article or handbook
Title:
The Estimation Programs Interface (EPI) SuiteTM v4.00
Author:
US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC)
Year:
2008
Bibliographic source:
United States Environmental Protection Agency

Materials and methods

Principles of method if other than guideline:
The Ecosar class program has been developed primarily for the evaluation of neutral organic compounds and organic classes with excess toxicity. The QSARs in the Ecosar program are developed for chemical classes based on measured test data that have been submitted by industry or they are developed by other sources for chemicals with similar structures, e.g. phenols. Using the measured aquatic toxicity values and estimated Kow values, regression equations can be developed for a class of chemicals. Toxicity values for new chemicals may then be calculated by inserting the Kow into the regression equation and correcting the resultant value for the molecular weight of the compound.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 002
Cas Number:
74-84-0
Molecular formula:
C2H6
Details on test material:
Estimate used neutral organics ECOSAR class
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data reported

Sampling and analysis

Analytical monitoring:
not required
Details on sampling:
No data reported

Test solutions

Vehicle:
not specified
Details on test solutions:
No data reported

Test organisms

Test organisms (species):
other: Fish, no other information
Details on test organisms:
No data reported

Study design

Test type:
other: QSAR calculation
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
No data reported

Test conditions

Hardness:
No data reported
Test temperature:
No data reported
pH:
No data reported
Dissolved oxygen:
No data reported
Salinity:
No data reported
Nominal and measured concentrations:
No data reported
Details on test conditions:
No data reported
Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
91.42 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
not specified
Details on results:
The value estimated is greater than the solubility of ethane in water.
Results with reference substance (positive control):
No data reported
Reported statistics and error estimates:
No data reported

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Remarks:
Calculation
Conclusions:
The 96 hour LC50 for fish is estimated to be 91.42 mg/L in fresh water. The value estimated is greater than the solubility of ethane in water.
Executive summary:

No experimental data are available for the effect of ethane on the short term toxicity of fish so QSAR calculations have been used to estimate result. ECOSAR Program v1.00. in EPI Suite v4.00 was used which is acceptable with restrictions. The 96 hour LC50 for fish is estimated to be 91.42 mg/L in fresh water. The value estimated is greater than the solubility of ethane in water.