Registration Dossier
Registration Dossier
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EC number: 403-810-6 | CAS number: 140876-13-7 C.I. REACTIVE YELLOW 138:1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Potassium sodium 3,3'-(3(or4)-methyl-1,2-phenylenebis(imino(6-chloro)-1,3,5-triazine-4,2-diylimino(2-acetamido-5-methoxy)-4,1-phenylenazo)dinaphthalene-1,5-disulfonate
- EC Number:
- 403-810-6
- EC Name:
- Potassium sodium 3,3'-(3(or4)-methyl-1,2-phenylenebis(imino(6-chloro)-1,3,5-triazine-4,2-diylimino(2-acetamido-5-methoxy)-4,1-phenylenazo)dinaphthalene-1,5-disulfonate
- Cas Number:
- 140876-13-7
- Molecular formula:
- C51H42Cl2N16O16S4
- IUPAC Name:
- 3-{2-[4-({4-chloro-6-[(2-{[4-chloro-6-({4-[2-(4,8-disulfonaphthalen-2-yl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}amino)-1,3,5-triazin-2-yl]amino}-5-methylphenyl)amino]-1,3,5-triazin-2-yl}amino)-2-acetamido-5-methoxyphenyl]diazen-1-yl}naphthalene-1,5-disulfonic acid; 3-{2-[4-({4-chloro-6-[(2-{[4-chloro-6-({4-[2-(4,8-disulfonaphthalen-2-yl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}amino)-1,3,5-triazin-2-yl]amino}-6-methylphenyl)amino]-1,3,5-triazin-2-yl}amino)-2-acetamido-5-methoxyphenyl]diazen-1-yl}naphthalene-1,5-disulfonic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium TA 1535, TA 1537, TA 98, TA 100, TA 1538 Escherichia coli: WP2
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): CA 1 ... 5380 µg/plate
Concentration range in the main test (without metabolic activation): CA 1 ... 5380 µg/plate - Vehicle / solvent:
- solvent: Dimethylsulfoxide
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>5300 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>5300 µg/plate)
- Additional information on results:
- Observations:
Positive, concentration-related results were observed in TA 1537, TA 1538 and TA 98 (with and without metabolic activation) and in TA 100 (with activation). For each strain the positive effect was much greater with activation.
Negative results were observed for TA 1535 (with and without metabolic activation) and TA 100 (without activation). - Remarks on result:
- other: other: main test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
None.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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