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EC number: 430-550-0 | CAS number: 1671-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 September - 28 September 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 430-550-0
- EC Name:
- -
- Cas Number:
- 1671-49-4
- Molecular formula:
- C8H9NO4S
- IUPAC Name:
- 4-methanesulfonyl-1-methyl-2-nitrobenzene
- Details on test material:
- - Physical state: white powdery solid
- Storage condition of test material: ambient temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adults
- Weight at study initiation: 2414-3283 g
- Housing: individually, in cages suitable for rabbits of this strain and weight range expected during the course of the study
- Diet: STANRAB SQC ad libitum
- Water: mains water ad libitum
- Acclimation period: at least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 17±2°C
- Humidity: 40-70%
- Air changes: approximately 25 per hr
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 13 September 1995 To: 28 September 1995
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- corn oil
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approximately 500 mg
- The test substance was moistened to a dry paste with approximately 0.5 mL corn oil
VEHICLE
- Amount(s) applied (volume or weight with unit): the test substance was moistened with approximately 0.5 mL corn oil to a dry paste - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: approximately 2.5 cm x 2.5 cm of the left flank
- % coverage: not reported
- Type of wrap if used: the treated area was covered with a piece of 8-ply surgical gauze which was secured by two strips of surgical tape. This was covered by a piece of impermeable rubber sheeting wrapped once around the trunk of the animal and secured with adhesive impermeable polyethylene tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the application site was cleansed free of any residual test material using clean swabs of absorbent cotton wool and clean warm water, then dried with clean tissue paper.
- Time after start of exposure: approximately 4 hours
SCORING SYSTEM
- The Draize scale (Draize JH (1959) Third printing, 1975. 'Dermal Toxicity' in 'Appraisal of the safety of chemicals in food, drugs and cosmetics'. Association of Food and Drug Officials of the US, pp46-59) was used to assess the degree of erythema and oedema approximately 30 minutes and 1, 2, 3 and (for one animal) 4 days after removal of the dressings. Any other signs of skin irritation were also noted.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 30 minutes after decontamination
- Score:
- 1
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- no changes at any timepoint
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2, #3
- Time point:
- other: 30 minutes after decontamination
- Score:
- 1
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- no changes at any timepoint
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- no changes at any timepoint
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 48 hours
Any other information on results incl. tables
Table1: Individual and mean skin irritation scores according to the Draize scheme
Time |
Erythema |
Oedema |
||||
Animal number |
2 |
10 |
11 |
2 |
10 |
11 |
after 1 hour |
1 |
1 |
1 |
1 |
1 |
1 |
after 24 hours |
1 |
0 |
1 |
0 |
0 |
1 |
after 48 hours |
1 |
0 |
1 |
0 |
0 |
0 |
after 72 hours |
1 |
0 |
0 |
0 |
0 |
0 |
mean score 24-72 hours |
1 |
0 |
0.7 |
0 |
0 |
0.3 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This test substance is a slight irritant following a single four-hour application to rabbit skin. The substance does not meet the criteria for classification.
- Executive summary:
A group of 3 female rabbits received a single four-hour application of 500 mg of the test substance to the shorn flank. The animals were assessed for up to 4 days for any signs of skin irritation.
Very slight erythema was seen in all three animals approximately 1 hour after decontamination and in two animals for the following 2 or 3 days. Very slight oedema was seen in all three animals approximately 1 hour after decontamination and in one animal for 1 day. All signs of irritation had completely resolved 4 days after application.
The test substance is a slight irritant following a single four-hour application to rabbit skin.
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