Registration Dossier
Registration Dossier
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EC number: 257-158-0 | CAS number: 51368-55-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Qualifier:
- according to guideline
- Guideline:
- other: EPA OPPTS harmonised guidelines
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Isopropyl 2-bromo-2-methylpropionate
- EC Number:
- 257-158-0
- EC Name:
- Isopropyl 2-bromo-2-methylpropionate
- Cas Number:
- 51368-55-9
- Molecular formula:
- C7H13BrO2
- IUPAC Name:
- isopropyl 2-bromo-2-methylpropionate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9
- Test concentrations with justification for top dose:
- 5 doses beetween 50 to 5000 µg/plate
Controls
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Dimethyl sulphoxide
- Positive controls:
- yes
- Positive control substance:
- other: standard control chemicals
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Remarks:
- 5000 µg/plate
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: strain/cell type: TA 100, TA 102, TA 1537
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- The test material was considered to be mutagenic under the conditions of this test.
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