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EC number: 203-640-0 | CAS number: 109-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-04-09 - 1991-04-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions (e.g. non-GLP, no analytical verification of test item concentrations)
- Qualifier:
- according to guideline
- Guideline:
- other: EC Directive 79/831/EEC, Annex V, Part C
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Methylmorpholin
- Substance type: pure active substance
- Physical state: liquid
- Analytical purity: >= 99%
- Lot/batch No.: Tank 8; Prod. no. 2 019 120/1-53
- Stability under test conditions: stable - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solution prepared (100 mg/L)
- Differential loading: yes
- Controls: negative control (test medium only)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): not applicable
- Concentration of vehicle in test medium (stock solution and final test solution): not applicable
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Waterflea
- Strain: Institut National de Recherche Chimique Appliquée, France
- Source: originally supplied from 'Institut National de Recherche Chimique appliquee, France', and has been bred from 1978 in the Laboratories of BASF
- Age at study initiation (mean and range, SD): 2 to 24 h
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- total hardness: 2.71 mmol/L
- Test temperature:
- 21.3 to 21.5 °C
- pH:
- 7.9 to 8.6
- Dissolved oxygen:
- 7.9 to 8.3 mg/L
- Nominal and measured concentrations:
- nominal: 0 (control), 12.5, 25, 50, and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 20-mL reagent tubes with flat bottom
- Material, size, headspace, fill volume: 10 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline (synthetic freshwater prepared on the basis of clean and deionized water with a conductivity of < 0.05 µS/cm)
- Alkalinity: up to pH 4.3: 0.90 ± 0.10 mmol/L
- Ca/Mg ratio: 4:1
- Conductivity: 674 µSiemens/cm
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8 h
- Light intensity: diffuse light
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
- temperature: After 0, 24, and 48 h
- pH values and dissolved oxygen: After 0 and 48 hours
- Mobile daphnids: after 0, 3, 6, 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2 - Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- Short-term toxicity of the test substance to invertebrates was investigated by exposing Daphnia magna (waterflea) during 48 hours in a static test, according to the EC directive 79/831/EEC, Annex V, Part C guideline. This resulted in an unbounded EC50 value of > 100 mg/L and a NOEC of 100 mg/L.
Reference
Mobility:
Concentration (mg/L) |
Mobile daphnids after |
|||
3 h |
6 h |
24 h |
48 h |
|
Control |
20 |
20 |
20 |
20 |
12.5 |
20 |
20 |
20 |
20 |
25.0 |
20 |
20 |
20 |
20 |
50.0 |
20 |
20 |
20 |
20 |
100.0 |
20 |
20 |
20 |
19 |
pH:
Concentration (mg/L) |
0 h |
48 h |
Control |
8.0 |
7.9 |
12.5 |
8.1 |
8.0 |
25.0 |
8.2 |
8.0 |
50.0 |
8.4 |
8.1 |
100.0 |
8.6 |
8.1 |
Oxygen content:
- range of O2 (mg/L): 7.9 - 8.3
Temperature:
- range (°C): 21.3 - 21.5
Description of key information
Although the key study provided an unbounded EC50 value, a bounded value is used as key value for the chemical safety assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Short-term toxicity of the test substance to invertebrates was investigated by exposing Daphnia magna (waterflea) during 48 hours in a static test, according to the EC directive 79/831/EEC, Annex V, Part C guideline. This resulted in an unbounded EC50 value of > 100 mg/L and a NOEC of 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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