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EC number: 231-626-4 | CAS number: 7659-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2002-08-16 to 2002-12-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- yes
- Remarks:
- No identification of degradation products
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-ethylhexyl mercaptoacetate
- EC Number:
- 231-626-4
- EC Name:
- 2-ethylhexyl mercaptoacetate
- Cas Number:
- 7659-86-1
- Molecular formula:
- C10H20O2S
- IUPAC Name:
- 2-ethylhexyl 2-sulfanylacetate
- Details on test material:
- - Physical state: colorless liquid
- Storage condition of test material: at room temperature and protected from light
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent product:
Preliminary test
pH 4.0, 7.0 and 9.0
0 hour, 2.4 hours and 72 hours at 50°C.
Main test
First temperature (50°C)
pH 4.0, 7.0 and 9.0
· 0, 1.17, 1.50, 1.83, 2.17, 2.50 and 2.83 hours (pH 4.0),
· 0, 0.50, 0.83, 1.50, 1.83, 2.17, 2.50 and 2.83 hours (pH 7.0),
· 0, 1.17, 1.50, 1.83, 2.17, 2.50 and 2.83 hours (pH 9.0).
Second temperature (66°C)
pH 4.0 and 7.0
· 0, 0.50, 0.83, 1.17, 1.50, 1.83 and 2.17 hours (pH 4.0),
· 0, 0.50, 0.83, 1.17, 1.50, 1.83 and 2.17 hours (pH 7.0).
pH 9.0
· 0, 0.50, 0.83, 1.17, 1.50, 1.75 and 2.00 hours (pH 9.0).
Third temperature (80°C)
pH 4.0, 7.0 and 9.0
· 0, 0.50, 0.67, 0.83, 1.00, 1.17 and 1.33 hours (pH 4.0),
· 0, 0.33, 0.50, 0.67, 0.83, 1.00, 1.17, 1.33 and 1.50 hours (pH 7.0),
· 0, 0.33, 0.50, 0.67, 0.83, 1.00 and 1.17 hours (pH 9.0).
Repeated temperature (66°C)
pH 4.0, 7.0 and 9.0
· 0, 0.83, 1.17, 1.50, 1.83, 2.17 and 2.50 hours (pH 4.0),
· 0, 0.50, 0.83, 1.17, 1.50, 1.83 and 2.17 hours (pH 7.0),
· 0, 0.50, 0.83, 1.17, 1.50, 1.83 and 2.17 hours (pH 9.0).
Temperature for pH 1.2 (37°C)
pH 4.0, 7.0 and 9.0
· 0, 2.50, 3.00, 3.50, 4.50, 5.50, 6.50 and 7,5 hours.
- Sampling method:
An aliquot of each sample was extracted and analyzed by Gas Liquid Chromatography with Flame Ionization Detection (FID).
- Sampling intervals/times for pH measurements:
Same as "Sampling intervals for the parent product"
- Other observation, if any (e.g.: precipitation, color change etc.):
Colors of the resulting solutions were observed at the end of tests. - Buffers:
- An aliquot (mg) of test system was dissolved in a 100-mL volumetric flask. The flask was made to volume with ethylic alcohol (stock solution).
An aliquot of stock solution was introduced in a volumetric flask and each flask was made to volume with respectively buffer
pH 4.0, 7.0 and 9.0. These obtained solutions were transferred in test bottles protected from light.
Preliminary test
pH 4.0, 7.0 and 9.0 at 50°C
Amount of the test item used for preparation of stock solution: 103.1 mg.
Volume of stock solution used for preparation of buffer solution: 0.2 mL.
Volume of volumetric flask used for buffer solution: 100 mL.
Main test
First temperature (50°C)
pH 4.0, 7.0 and 9.0
Amount of the test item used for preparation of stock solution: 51.4 mg.
Volume of stock solution used for preparation of buffer solution: 0.9 mL.
Volume of volumetric flask used for buffer solution: 200 mL.
Second temperature (66°C)
pH 4.0 and 7.0
Amount of the test item used for preparation of stock solution: 50.0 mg.
Volume of mother solution used for preparation of buffer solution: 0.45 mL.
Volume of volumetric flask used for buffer solution: 100 mL.
pH 9.0
Amount of the test item used for preparation of stock solution: 50.6 mg.
Volume of stock solution used for preparation of buffer solution: 0.47 mL.
Volume of volumetric flask used for buffer solution: 100 mL.
Third temperature (80°C)
pH 4.0, 7.0 and 9.0
Amount of the test item used for preparation of stock solution: 53.5 mg.
Volume of stock solution used for preparation of buffer solution: 0.9 mL.
Volume of volumetric flask used for buffer solution: 200 mL.
Repeated temperature (66°C)
pH 4.0, 7.0 and 9.0
Amount of the test item used for preparation of stock solution: 43.8 mg.
Volume of stock solution used for preparation of buffer solution: 0.9 mL.
Volume of volumetric flask used for buffer solution: 100 mL.
Temperature for pH 1.2 (37°C)
pH 4.0, 7.0 and 9.0
Amount of the test item used for preparation of stock solution: 99.4 mg.
Volume of stock solution used for preparation of buffer solution: 0.6 mL
Volume of volumetric flask used for buffer solution: 250 mL
Duration of testopen allclose all
- Duration:
- 2.83 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.93 mg/L
- Duration:
- 2.83 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 2 mg/L
- Duration:
- 2.83 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 2.02 mg/L
- Duration:
- 2.17 h
- pH:
- 4
- Temp.:
- 66 °C
- Initial conc. measured:
- 1.78 mg/L
- Duration:
- 2.17 h
- pH:
- 7
- Temp.:
- 66 °C
- Initial conc. measured:
- 1.8 mg/L
- Duration:
- 2 h
- pH:
- 9
- Temp.:
- 66 °C
- Initial conc. measured:
- 2.03 mg/L
- Duration:
- 1.33 h
- pH:
- 4
- Temp.:
- 80 °C
- Initial conc. measured:
- 1.77 mg/L
- Duration:
- 1.5 h
- pH:
- 7
- Temp.:
- 80 °C
- Initial conc. measured:
- 1.7 mg/L
- Duration:
- 1.17 h
- pH:
- 9
- Temp.:
- 80 °C
- Initial conc. measured:
- 1.77 mg/L
- Duration:
- 7.5 h
- pH:
- 1.2
- Temp.:
- 38 °C
- Initial conc. measured:
- 1.59 mg/L
- Number of replicates:
- 2 replicates per assay (temperature and pH) were measured.
At 66°C, tests were repeated. Therefore, at 66°C and all tested pH, 4 replicates were measured. - Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- The concentrations of 2-EHTG were determined from a calibration curve obtained by linear regression analysis of respective ratio test item peak area/Internal Standard peak area versus concentration of standard solutions ranging from 0.5 to 50 mg/L.
Results and discussion
- Preliminary study:
- During the preliminary test, the degradation of 2-EHTG, at each pH value, indicated an hydrolysis lower than 50% after 2.4 hours and higher than 10% after 3 days. 2-EHTG was considered as hydrolytically unstable. The hydrolysis rate was then determined at three different temperatures (50°C, 66°C (twice) and 80°C) for each buffer and one temperature (37°C) for pH = 1.2. The determination was performed to cover approximately 20-70% hydrolysis.
- Transformation products:
- not measured
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 54
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 2.83 h
- % Recovery:
- 51
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 2.83 h
- % Recovery:
- 55
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 2.83 h
- % Recovery:
- 32
- pH:
- 4
- Temp.:
- 66 °C
- Duration:
- 2.17 h
- % Recovery:
- 31
- pH:
- 7
- Temp.:
- 66 °C
- Duration:
- 2.17 h
- % Recovery:
- 35
- pH:
- 9
- Temp.:
- 66 °C
- Duration:
- 2 h
- % Recovery:
- 35
- pH:
- 4
- Temp.:
- 80 °C
- Duration:
- 1.33 h
- % Recovery:
- 31
- pH:
- 7
- Temp.:
- 80 °C
- Duration:
- 1.5 h
- % Recovery:
- 30
- pH:
- 9
- Temp.:
- 80 °C
- Duration:
- 1.17 h
- % Recovery:
- 45
- pH:
- 1.2
- Temp.:
- 38 °C
- Duration:
- 7.5 h
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- ca. 12 h
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- ca. 12 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- ca. 16 h
- pH:
- 1.2
- Temp.:
- 37 °C
- DT50:
- ca. 6.8 h
- Details on results:
- The values of the t½ at 25°C for each pH were obtained by extrapolation, as no test was conducted at this temperature.
For total recovery of test substance, mean results for n=2 are reported at all temperatures except at 66°C, where mean results are reported for n = 4.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The substance was found to be hydrolytically unstable at 25°C, with estimated half-lives ranging from 12 to 16 hours at pH from 4 to 9, respectively.
- Executive summary:
The hydrolysis rate was determined according to the test OECD Guideline 111. The substance was found to be hydrolytically unstable at 25°C, with estimated half-lives ranging from 12 to 16 hours at pH from 4 to 9, respectively. Half-life was 6.8 at 37°C and pH 1.2.
Advanced tests results were the following:
Kobs = 0.0580 h-1 and t½ = 12 h at 25°C for pH 4.0 (estimation),
Kobs = 0.0594 h-1 and t½ = 12 h at 25°C for pH 7.0 (estimation),
Kobs = 0.0422 h-1 and t½ = 16 h at 25°C for pH 9.0 (estimation),
Kobs = 0.102 h-1 and t½ = 6.8 h at 37°C for pH 1.2.
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