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EC number: 209-097-6 | CAS number: 555-43-1
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d) ≥ 1000 mg/kg dw for Eisenia fetida (OECD 207)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of glycerol tristearate (CAS No. 555-43-1) to soil macroorganisms are available.Therefore, toxicity data from an analogue category member, propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) are used as read-across. Both substances are esters formed from the combination between fatty acids and glycerol. Propane-1,2,3-triyl trisheptanoate and glycerol tristearate are triglycerides (the three hydroxyl functional groups of the glycerol molecule are esterified with fatty acids), differing only in the length of the C-chain of their fatty acid components (C7 and C18 respectively).Their behaviour in the soil compartment is expected to be very similar based on a common high adsorption potential to solid particles (log Pow (>8)) and readily biodegradable nature (they will not be persistent in soil).Nevertheless, the bioavailability of glycerol tristearate to soil organisms is expected to be lower than that of propane-1,2,3-triyl trisheptanoate, due to its high molecular weight (> 700 g/Mol) which can hinder the crossing of biological membranes (Guidance on information requirements and chemical safety assessment, Chapter R.11 (ECHA, 2008)). Based on this information, reading-across from propane-1,2,3-triyl trisheptanoate is justified and can be considered as a worst-case approach for glycerol tristearate.
The toxicity ofpropane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) to earthworms was evaluated by Muckle (2012). This test was performed according to OECD 207, under GLP conditions. Eisenia fetida was exposed to the test substance for 14 days at a concentration of 1000 mg/kg dw (limit test). After the exposure period, no significant mortality was reported in either treatment or control groups. Furthermore, no significant differences on earthworm biomass were observed. The resulting NOEC was thus determined to be ≥ 1000 mg/kg dw.
Based on the results obtained for the structurally related analogue (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5), glycerol tristearate is not expected to show toxicity to soil macroorganisms.
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