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Diss Factsheets
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EC number: 204-436-4 | CAS number: 120-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other above-ground organisms
Administrative data
- Endpoint:
- toxicity to other above-ground organisms
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the mode of action of the chemosterilants 2-Imidazolidinone and 4-Imidazolidin-2-one in the house fly and in the large milkweed bug
- Author:
- Schaefer C.H.
- Year:
- 1 967
- Bibliographic source:
- Life Sciences Vol . 6, pp. 2677-2683, 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One-day-old adult female house flies and large milkweed bugs were injected with one µL of an aqueous solution containing 5 µL of 2-imidazolidinone or 4-imidazolin-2-one. Ten insects per treatment were held in a 125 mL Erlenmeyer flask and covered with cheesecloth. All treatments and analyses were made in duplicate.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-imidazolidone
- EC Number:
- 204-436-4
- EC Name:
- 2-imidazolidone
- Cas Number:
- 120-93-4
- Molecular formula:
- C3H6N2O
- IUPAC Name:
- 2-imidazolidone
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: House Fly and Large Milkweed Bug
Study design
- Study type:
- laboratory study
- Limit test:
- yes
- Total exposure duration:
- 24 h
Test conditions
- Details on test conditions:
- - Animals per treatment: 10
- Test vessel: 125 mL Erlenmeyer flask covered with cheesecloth
- Number of replicates: 2 - Nominal and measured concentrations:
- The animals were injected with 5 µg/µL of the test substance.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- other: Average metabolism of test substance
- Effect conc.:
- 68 other: %
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks on result:
- other: Adult House Fly
- Key result
- Duration:
- 24 h
- Dose descriptor:
- other: Average metabolism of test substance
- Effect conc.:
- 0 other: %
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks on result:
- other: Adult Milkweed Bug
Any other information on results incl. tables
Average excretion and metabolism in house flies and large milkweed bugs 24 hours after the injection of 5 µg per insect:
Species |
Quantity (µg) of Sterilant |
% of total dose |
||||
|
Tissues |
Feces |
Metabolized |
Tissues |
Feces |
Metabolized |
Adult House Fly |
0.8 |
0.8 |
3.4 |
16 |
16 |
68 |
Adult Large Milkweed Bug |
5.0 |
0.0 |
0.0 |
100 |
0 |
0 |
2-Imidazolidinone is a temporary sterilants in house flies (Musca domestica L.), but produce permanent effects in large milkweed bugs (Oncopeltus fasciatus Dallas). Flies are able to eliminate large amounts of the compound through excretion and metabolism, whereas neither method of elimination was found in milkweed bugs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.