Bis(2,4,4-trimethylpentyl)phosphinic acid

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 16 Feburary 2012 to 26 June 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

2011-08-31

Type of method:

effusion method: vapour pressure balance

Temp.:

25 °C

Vapour pressure:

0.002 Pa

Transition / decomposition:

no

Results run 1:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	38,74	3,874E-08	0,053781045	-1,269370762
81	354,15	0,002823662	39,44	3,944E-08	0,054752824	-1,261593472
82	355,15	0,002815712	39,54	3,954E-08	0,05489165	-1,260493714
83	356,15	0,002807806	39,74	3,974E-08	0,055169301	-1,258302516
84	357,15	0,002799944	44,83	4,483E-08	0,062235525	-1,205961640
85	358,15	0,002792126	48,42	4,842E-08	0,067219365	-1,172505594
86	359,15	0,002784352	50,52	5,052E-08	0,070134703	-1,154067037
87	360,15	0,002776621	52,42	5,242E-08	0,07277239	-1,138033362
88	361,15	0,002768933	53,62	5,362E-08	0,074438297	-1,128203569
89	362,15	0,002761287	56,61	5,661E-08	0,078589183	-1,104637224
90	363,15	0,002753683	57,71	5,771E-08	0,080116265	-1,096279304

A plot of log Vp versus reciprocal temperature fur Run 1 gives the following statistical data using an unweighted least squares treatment:

Slope	-2,54*10^3	Intercept	5,92
Standard deviation	185	Standard deviation	0,515

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-2.54*10³/ temp(K)]+5.92

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.62

Results run 2:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	37,34	3,734E-08	0,051837486	-1,285356065
81	354,15	0,002823662	37,24	3,724E-08	0,051698661	-1,286520706
82	355,15	0,002815712	37,74	3,774E-08	0,052392789	-1,280728483
83	356,15	0,002807806	39,84	3,984E-08	0,055308127	-1,257211049
84	357,15	0,002799944	41,04	4,104E-08	0,056974034	-1,244323027
85	358,15	0,002792126	45,33	4,533E-08	0,062929653	-1,201144660
86	359,15	0,002784352	47,03	4,703E-08	0,065289689	-1,185155400
87	360,15	0,002776621	50,02	5,002E-08	0,069440575	-1,158386691
88	361,15	0,002768933	56,61	5,661E-08	0,078589183	-1,104637224
89	362,15	0,002761287	53,82	5,382E-08	0,074715949	-1,126586685
90	363,15	0,002753683	60,21	6,021E-08	0,083586906	-1,077861752

 A plot of log Vp versus reciprocal temperature fur Run 2 gives the following statistical data using an unweighted least squares treatment:

Slope	-2,87*10^3	Intercept	6,81
Standard deviation	218	Standard deviation	0,609

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-2.87*10³/ temp(K)]+6.81

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.81

Results run 3:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	34,45	3,445E-08	0,047825426	-1,320341152
81	354,15	0,002823662	37,74	3,774E-08	0,052392789	-1,280728483
82	355,15	0,002815712	38,74	3,874E-08	0,053781045	-1,269370762
83	356,15	0,002807806	41,63	4,163E-08	0,057793106	-1,238123968
84	357,15	0,002799944	41,83	4,183E-08	0,058070757	-1,236042514
85	358,15	0,002792126	44,83	4,483E-08	0,062235525	-1,205961640
86	359,15	0,002784352	48,12	4,812E-08	0,066802888	-1,175204760
87	360,15	0,002776621	52,22	5,222E-08	0,072494739	-1,139693511
88	361,15	0,002768933	55,91	5,591E-08	0,077617404	-1,110040886
89	362,15	0,002761287	57,01	5,701E-08	0,079144486	-1,101579338
90	363,15	0,002753683	60,01	6,001E-08	0,083309254	-1,079306752

 A plot of log Vp versus reciprocal temperature fur Run 3 gives the following statistical data using an unweighted least squares treatment:

Slope	-3,10*10^3	Intercept	7,45
Standard deviation	118	Standard deviation	0,331

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-3.10*10³/ temp(K)]+7.45

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.94

Results run 4:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	37,14	3,714E-08	0,051559835	-1,287688479
81	354,15	0,002823662	37,94	3,794E-08	0,05267044	-1,278433052
82	355,15	0,002815712	39,54	3,954E-08	0,05489165	-1,260493714
83	356,15	0,002807806	37,34	3,734E-08	0,051837486	-1,285356065
84	357,15	0,002799944	42,33	4,233E-08	0,058764885	-1,230882110
85	358,15	0,002792126	42,23	4,223E-08	0,058626059	-1,231909297
86	359,15	0,002784352	44,03	4,403E-08	0,061124692	-1,213781693
87	360,15	0,002776621	48,82	4,882E-08	0,067774668	-1,168932604
88	361,15	0,002768933	53,42	5,342E-08	0,074160646	-1,129826495
89	362,15	0,002761287	59,71	5,971E-08	0,082892778	-1,081483308
90	363,15	0,002753683	62,6	6,260E-08	0,086904838	-1,060956046

 A plot of log Vp versus reciprocal temperature fur Run 4 gives the following statistical data using an unweighted least squares treatment:

Slope	-2.98*10^3	Intercept	7,12
Standard deviation	333	Standard deviation	0,930

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-2.98*10³/ temp(K)]+7.12

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.88

Results run 5:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	36,54	3,654E-08	0,050726881	-1,294761836
81	354,15	0,002823662	37,64	3,764E-08	0,052253963	-1,281880764
82	355,15	0,002815712	35,24	3,524E-08	0,048922148	-1,310494479
83	356,15	0,002807806	39,74	3,974E-08	0,055169301	-1,258302516
84	357,15	0,002799944	42,13	4,213E-08	0,058487234	-1,232938920
85	358,15	0,002792126	45,13	4,513E-08	0,062652002	-1,203065045
86	359,15	0,002784352	48,02	4,802E-08	0,066664063	-1,176108223
87	360,15	0,002776621	51,52	5,152E-08	0,071522959	-1,145554524
88	361,15	0,002768933	46,83	4,683E-08	0,065012038	-1,187006221
89	362,15	0,002761287	54,51	5,451E-08	0,075673845	-1,121054197
90	363,15	0,002753683	59,21	5,921E-08	0,08219865	-1,085135318

A plot of log Vp versus reciprocal temperature fur Run 5 gives the following statistical data using an unweighted least squares treatment:

Slope	-2.73*10^3	Intercept	6.42
Standard deviation	282	Standard deviation	0.787

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-2.73*10³/ temp(K)]+6.42

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.74

Results run 6:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,00283166	35,44	3,544E-08	0,0491998	-1,308036666
81	354,15	0,00282366	36,44	3,644E-08	0,05058806	-1,295952010
82	355,15	0,00281571	36,64	3,664E-08	0,05086571	-1,293574914
83	356,15	0,00280781	40,84	4,084E-08	0,05669638	-1,246444645
84	357,15	0,00279994	41,93	4,193E-08	0,05820958	-1,235005516
85	358,15	0,00279213	45,53	4,553E-08	0,06320731	-1,199232728
86	359,15	0,00278435	43,23	4,323E-08	0,06001432	-1,221745143
87	360,15	0,00277662	49,02	4,902E-08	0,06805232	-1,167157072
88	361,15	0,00276893	52,92	5,292E-08	0,07346652	-1,133910543
89	362,15	0,00276129	57,51	5,751E-08	0,07983861	-1,097787011
90	363,15	0,00275368	61,4	6,140E-08	0,08523893	-1,069362008

A plot of log Vp versus reciprocal temperature fur Run 6 gives the following statistical data using an unweighted least squares treatment:

Slope	-3.07*10^3	Intercept	7.37
Standard deviation	222	Standard deviation	0.619

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-3.07*10³/ temp(K)]+7.37

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.93

Results run 7:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	35,64	3,564E-08	0,049477451	-1,305592683
81	354,15	0,002823662	37,14	3,714E-08	0,051559835	-1,287688479
82	355,15	0,002815712	37,84	3,784E-08	0,052531615	-1,279579251
83	356,15	0,002807806	38,14	3,814E-08	0,052948091	-1,276149690
84	357,15	0,002799944	41,34	4,134E-08	0,057390511	-1,241159906
85	358,15	0,002792126	45,93	4,593E-08	0,063762607	-1,195433933
86	359,15	0,002784352	46,53	4,653E-08	0,064595561	-1,189797326
87	360,15	0,002776621	52,42	5,242E-08	0,072772390	-1,138033362
88	361,15	0,002768933	50,52	5,052E-08	0,070134703	-1,154067037
89	362,15	0,002761287	54,31	5,431E-08	0,075396194	-1,122650576
90	363,15	0,002753683	55,81	5,581E-08	0,077478578	-1,110818356

 

A plot of log Vp versus reciprocal temperature fur Run 7 gives the following statistical data using an unweighted least squares treatment:

Slope	-2.73*10^3	Intercept	6.40
Standard deviation	185	Standard deviation	0.516

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-2.73*10³/ temp(K)]+6.40

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.74

Results run 8:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	33,95	3,395E-08	0,047131298	-1,326690600
81	354,15	0,002823662	31,55	3,155E-08	0,043799483	-1,358531015
82	355,15	0,002815712	37,84	3,784E-08	0,052531615	-1,279579251
83	356,15	0,002807806	36,14	3,614E-08	0,050171579	-1,299542231
84	357,15	0,002799944	42,03	4,203E-08	0,058348408	-1,233970989
85	358,15	0,002792126	41,63	4,163E-08	0,057793106	-1,238123968
86	359,15	0,002784352	48,02	4,802E-08	0,066664063	-1,176108223
87	360,15	0,002776621	48,22	4,822E-08	0,066941714	-1,174303173
88	361,15	0,002768933	46,33	4,633E-08	0,064317910	-1,191668079
89	362,15	0,002761287	52,92	5,292E-08	0,073466518	-1,133910543
90	363,15	0,002753683	53,73	5,373E-08	0,074577123	-1,127394375

 

A plot of log Vp versus reciprocal temperature fur Run 8 gives the following statistical data using an unweighted least squares treatment:

Slope	-2.88*10^3	Intercept	6.80
Standard deviation	291	Standard deviation	0.813

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-2.88*10³/ temp(K)]+6.80

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -2.85

Results run 9:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	34,65	3,465E-08	0,048103077	-1,317827140
81	354,15	0,002823662	35,74	3,574E-08	0,049616277	-1,304375831
82	355,15	0,002815712	36,34	3,634E-08	0,050449230	-1,297145456
83	356,15	0,002807806	39,14	3,914E-08	0,054336348	-1,264909557
84	357,15	0,002799944	41,53	4,153E-08	0,057654280	-1,239168448
85	358,15	0,002792126	43,13	4,313E-08	0,059875490	-1,222750921
86	359,15	0,002784352	46,93	4,693E-08	0,065150863	-1,186079825
87	360,15	0,002776621	51,22	5,122E-08	0,071106482	-1,148090805
88	361,15	0,002768933	53,12	5,312E-08	0,073744169	-1,132272312
89	362,15	0,002761287	57,91	5,791E-08	0,080393916	-1,094776814
90	363,15	0,002753683	79,08	7,908E-08	0,109783300	-0,959463718

 

A plot of log Vp versus reciprocal temperature fur Run 9 gives the following statistical data using an unweighted least squares treatment:

Slope	-3.97*10^3	Intercept	9.89
Standard deviation	435	Standard deviation	1.22

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-3.97*10³/ temp(K)]+9.89

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -3.43

Results run 10:

Temperature (°C)	Temperature (K)	Reciprocal temperature (K^-1)	Mass difference (µg)	Mass difference (kg)	Vapour pressure (Pa)	Log Vp
80	353,15	0,002831658	34,75	3,475E-08	0,048241903	-1,316575570
81	354,15	0,002823662	30,75	3,075E-08	0,042688878	-1,369685259
82	355,15	0,002815712	36,74	3,674E-08	0,051004533	-1,292391227
83	356,15	0,002807806	34,45	3,445E-08	0,047825426	-1,320341152
84	357,15	0,002799944	40,14	4,014E-08	0,055724604	-1,253953011
85	358,15	0,002792126	38,44	3,844E-08	0,053364568	-1,272747000
86	359,15	0,002784352	46,03	4,603E-08	0,063901433	-1,194489404
87	360,15	0,002776621	49,82	4,982E-08	0,069162924	-1,160126656
88	361,15	0,002768933	55,11	5,511E-08	0,076506799	-1,116299968
89	362,15	0,002761287	57,21	5,721E-08	0,079422137	-1,100058431
90	363,15	0,002753683	61,4	6,140E-08	0,085238931	-1,069362008

 

A plot of log Vp versus reciprocal temperature fur Run 10 gives the following statistical data using an unweighted least squares treatment:

Slope	-3.75*10^3	Intercept	9.25
Standard deviation	380	Standard deviation	1.06

The results obtained indicate the following vapour pressure relationship:

Log Vp= [-3.75*10³/ temp(K)]+9.25

The above yields a vapour pressure (Pa) at 298.15K with a common logarithm of -3.33

Summary of results:

The values of vapour pressure at 25 °C extrapolated from each graph are summarized in the following table:

Run	log Vp at 25 °C	Vapour pressure
1	-2,62	2,42*10^3
2	-2,81	1,54*10^3
3	-2,94	1,16*10^3
4	-2,88	1,33*10^3
5	-2,74	1,81*10^3
6	-2,93	1,17*10^3
7	-2,74	1,82*10^3
8	-2,85	1,42*10^3
9	-3,53	3,74*10^3
10	-3,33	4,66*10^3

Conclusions:

The vapour pressure of the test item has been determined to be 0.0024 Pa at 25°C

Executive summary:

The determination was carried out with the vapour pressure balance according to Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006 and GLP. No deviation from the guidelines was observed during the test.

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25°C. After evacuating the system, opening the shutter above the sample oven causes the escaping vapour jet to be directed at the scale pan. The difference in mass readings with the orifice covered and uncovered is proportional to the vapour pressure at the given oven temperature.

A preliminary run was undertaken over the temperature range 20 to 247 °C to provide information for a suitable temperature range for the determination. A final sequence of ten runs was started after a sample of test item had been under vacuum for approximately 46 hours. Temperature and pressure readings were taken between 80 and 90 °C with a one hour dwell at 80 °C between runs.

The test item didn't change in appearance under the conditions used in the determination.The vapour pressure of the test item has been determined to be 0.0024 Pa at 25 °C.