Registration Dossier
Registration Dossier
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EC number: 216-378-7 | CAS number: 1569-69-3
Endpoint summary
Administrative data
Description of key information
In the key skin irritation study (Lifestream Laboratories, 1969), application of 0.5 ml neat test substance to intact skin under an occlusive dressing caused severe erythema and moderate to severe edema. Skin bleaching was observed in all treated animals. Individual animal data are not reported, and there is no information on reversibility. However, the available data are sufficient to conclude that cyclohexylmercaptan is irritating to skin.
In an in vivo eye irritation study, cyclohexylmercaptan was reported to be slightly irritating according to the method of Kay and Calandra (1962), based on iritis and conjunctival redness. All effects were fully resolved by 96 hours. No corneal opacity was reported in any animal at any time point. Based on the available scores, the substance would not meet current EU criteria for classification as an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Only one study is available for skin and eye irritation (Lifestream Laboratories, 1969). The study did not follow OECD test guidelines and pre-dated GLP. However, sufficient details are presented and the protocols followed were sufficiently similar to current OECD methods to reach appropriate conclusions for classification and labelling purposes.
Justification for selection of skin irritation / corrosion endpoint:
The selected study is the only skin irritation study available for the registered substance. It was conducted according to a protocol that is similar to OECD 404 but was not compliant with GLP.
Justification for selection of eye irritation endpoint:
The selected study is the only eye irritation study available for the registered substance. It was conducted according to a protocol that is similar to OECD 404 but was not compliant with GLP.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the available in vivo skin and eye irritation study, the substance is classified as Skin Irritatant Category 2 with hazard statement H315: "Causes skin irritation" according to Regulation (EC) No 1272/2008. No classification is required for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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