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Diss Factsheets
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EC number: 213-050-5 | CAS number: 919-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1956
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but did not follow current guideline requirements, pre-dates GLP and cannot be used for classification. It does, however, add weight of evidence for the acute toxicity of 3-(triethoxysilyl)propiononitrile.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Female rats were exposed to substantially saturated vapour of 3-(triethoxysilyl)propiononitrile for a period of 8 hours. Non-guideline study that pre-dates GLP
- GLP compliance:
- no
- Test type:
- other: exposure to substantially saturated vapour
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(triethoxysilyl)propiononitrile
- EC Number:
- 213-050-5
- EC Name:
- 3-(triethoxysilyl)propiononitrile
- Cas Number:
- 919-31-3
- Molecular formula:
- C9H19NO3Si
- IUPAC Name:
- 3-(triethoxysilyl)propanenitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No data available.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION:
Concentrated vapour was generated at room temperature by passing air at 2.5 litres/minute through a fritted glass disc immersed in 50 ml of 3-(triethoxysilyl)propiononitrile.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- Substantially saturated vapour. Analytical concentration not determined.
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- No data available.
Results and discussion
- Preliminary study:
- Concentrations were not measured. One of six rats died.
- Mortality:
- One out of 6 rats died in response to the exposure.
- Clinical signs:
- other: No data available.
- Body weight:
- No data available.
- Gross pathology:
- No data available.
- Other findings:
- No data available.
Any other information on results incl. tables
Inhalation exposure to concentrated vapor generated at room temperature caused the death of 1 of 6 adult female rats.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In a non-guideline study, which pre-dates GLP, exposure of female rats to substantially saturated vapour of 3-(triethoxysilyl)propiononitrile (concentrations not specified) for 8 hours, resulted in the death of one out of six test animals. This study is assigned reliability 4 and cannot be used for classification. It does, however, add weight of evidence for the acute toxicity of 3-(triethoxysilyl)propiononitrile.
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