Registration Dossier
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EC number: 431-060-1 | CAS number: 153719-38-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Purpose: Determination of ErC/EbC 50 (0-72 h): Concentration at which the growth of algae is reduced by 50 % in relation to control.
Test system: Green Algae (Selenastrum capricornutum) Duration: 72 hours Guideline: OECD No. 201, Paris 1984; static system; Guideline 92/69/EEC, C.3; in addition FIFRA-guideline was taken into account. Deviations: none
Test substance: Identification: Code: CA 2343 A; Batch No.: P.503005; Purity: 96.7%
Design: Pretest showed that the EC50 (72h) will be at about 10 mg/l. Therefore the following nominal test concentrations were chosen for the main test 0.2, 0.4, 0.8, 1.6, 3.2, 6.4 and 12.8 mg test substance/l. After a preculture period of 3 days, Selenastrum capricornutum (initial cell density 10100 cells/ml) was exposed to nominal test concentrations.
Results: The temperature was maintained constant at 23+/-1 °C. Continuous illumination with cold white fluorescent light at 109umE/m2 sec. (approx. 8000 lux) was used. The pH of the test solutions was 8.0 - 8.1 and 8.0 - 8.2 at the start and and of exposure, respectively. The measured test concentrations of CA 2343 A were 0.19, 0.38, 0.76, 1.6, 2.9, 6.3, 12.7 mg/l and 0.18, 0.36, 0.71, 1.5, 2.9, 5.9, 12.0 mg/l at the start and the end of exposure, respectively. The measured concentrations were within 100 +/-20 % the nominal concentrations.
The following values are therefore based on nominal concentrations. Inhibition (growth rates): ErC 50 (0 - 72 h): 16.4 mg/l 95% confidence limit: 15.2 - 18.1 mg/l slope: 2.38 NOErC (0 - 72 h): 3.2 mg/l (significant on 5% level) Inhibition (areas under growth curves): EbC 50 (0 - 72 h): 8.6 mg/l 95% confidence limit: 7.3 - 10.2 mg/l slope: 2.69 NOEbC (0 - 72 h): 3.2 mg/l (significant on 5% level)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 16.4 mg/L
- EC10 or NOEC for freshwater algae:
- 3.2 mg/L
Additional information
Guideline Test Type |
Species |
Results |
Reference |
Reliability |
OECD 201 |
Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata) |
ErC50(0-72h): 16.4 mg/l NOErC (0-72h): 3.2 mg/l EbC50(0-72h): 8.6 mg/l NOEbC (0-72h): 3.2 mg/l |
Grade, R., Ciba-Geigy, 1996 |
Reliable without restrictions |
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