Registration Dossier
Registration Dossier
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EC number: 442-070-9 | CAS number: 329039-38-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72 h)= 931.3 mg/L (nominal)(Selenastrum capricornutum)
Key value for chemical safety assessment
Additional information
The toxicity of methyldiacetoxyisopropoxy silane (CAS No. 329039-38-5) to algae was investigated in a study by Eickhoff (2002), using Selenastrum capricornutum as test species. This test was conducted according to OECD Guideline 201 (Alga, Growth Inhibition test) under GLP conditions. The substance was incubated in test medium for 72 hours at 23 ± 2 °C. The concentrations of the main hydrolysis products (isopropanol and acetic acid) were determined by means of GC. Adverse effects on biomass and growth rate were observed in all treatment groups except for the algae in the 312.5 mg/L concentration, in which a slight hormetic effect was reported. Considering these results the 72h-EC50 was determined to be 931.3 mg/L (based on initial nominal test substance concentrations).
Acute algae toxicity data from acetic acid were found to range from 90-4000 mg/L (OECD SIDS for analogue substance Methyltriacetoxysilane (CAS No. 4253-34-3), 2005 and US HPV, 2001), whereas the toxicity threshold for isopropanol was determined to be 1800 mg/L (OECD SIDS, 1997).
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