Registration Dossier
Registration Dossier
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EC number: 604-958-6 | CAS number: 15448-47-2
Endpoint summary
Administrative data
Description of key information
A skin irritation study in animals performed to regulatory standards is not available. A relatively old study in rabbits indicated that application of undiluted or 10-20% aqueous propylene oxide may cause signs of skin irritation within minutes and scar formation with more lengthy exposures. In a more recent study, in which propylene oxide may have evaporated from the test sites, no skin irritation was observed. Overall, it appears that propylene oxide liquid may cause local irritation on contact with the skin. In light of eye irritation following exposure to propylene oxide vapour, it is considered that the liquid also has the potential to produce eye irritation. Classification according to Annex I of Directive 67/548/EC is proposed as follows: R36/37/38 Irritating to Eyes, Respiratory System and Skin.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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